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首页> 外文期刊>Cell cycle >Netrin-1 role in angiogenesis: To be or not to be a pro-angiogenic factor?
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Netrin-1 role in angiogenesis: To be or not to be a pro-angiogenic factor?

机译：Netrin-1在血管生成中的作用：是否成为促血管生成因子？

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摘要

Angiogenesis designates the formation of new vessels from preexisting ones, and occurs mainly during development. Tight control of this process is a prerequisite to avoid excess/defect in angiogenesis that are the underlying causes of several diseases conditions. Growing lines of evidences have indicated that some guidance cues are involved in regulation of vascular system elaboration, in addition to their role during nervous system development. In this way, netrin-1 has been involved in control of angiogenesis. However, a controversy has emerged regarding its action, since it was concluded from different studies that this protein was either a pro or an anti-angiogenic factor. Thus, netrin-1 role is still unclear. The aim of this review is to propose clues to explain previously reported discrepancies, in light of the dependence receptors model. Indeed, netrin-1 could likely favor angiogenesis, notably by blocking apoptosis induced by its unbound UNC5B receptor.
机译：血管生成指的是从先前存在的血管中形成新血管，并且主要发生在发育过程中。严格控制该过程是避免血管生成过度/缺陷的先决条件，血管生成是多种疾病状况的根本原因。越来越多的证据表明，除了在神经系统发育过程中的作用外，一些指导信号还参与了血管系统的调控。以这种方式，netrin-1已经参与了血管生成的控制。然而，关于它的作用已引起争议，因为根据不同的研究得出结论，该蛋白是促血管生成因子还是抗血管生成因子。因此，netrin-1的作用仍不清楚。这篇综述的目的是根据依赖性受体模型提出线索来解释先前报道的差异。确实，netrin-1可能会促进血管生成，特别是通过阻断其未结合的UNC5B受体诱导的凋亡。

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