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Yin yang 1 expression in human tumors.

机译:阴阳1在人类肿瘤中的表达。

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摘要

The Yin Yang 1 (YY1) transcription factor has been identified to target a plethora of potential target genes, the products of which are important for proliferation and differentiation. The mechanisms of YY1 action are related to its ability to initiate, activate or repress transcription depending on the context in which it binds. This article sheds a light on the role that YY1 plays in different human types of cancer, through the context of its expression levels. Moreover, we concentrate on the most relevant studies that have focused on YY1 regulation. we performed computational analysis on thirty-six publicly available Gene expression Omnibus (GeO) datasets, to further understand whether differences in YY1 transcript levels occur in different cancer types when compared with relative normal tissue, benign tumor or its metastatic counterpart. Our results suggest a dual role of YY1 in cancer development, either through overexpression or under-expression, depending on the tumor type.
机译:阴阳1(YY1)转录因子已被鉴定为靶向大量潜在的靶基因,其产物对于增殖和分化很重要。 YY1作用的机制与它启动,激活或抑制转录的能力有关,具体取决于它所结合的环境。本文通过其表达水平揭示了YY1在不同类型人类癌症中的作用。此外,我们专注于针对YY1调节的最相关研究。我们对36个公共可用的基因表达综合(GeO)数据集进行了计算分析,以进一步了解与相对正常组织,良性肿瘤或其转移性对应物相比,不同癌症类型中YY1转录水平是否发生差异。我们的研究结果表明,YY1在癌症的发展中具有双重作用,取决于肿瘤的类型,无论是过表达还是过表达。

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