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首页> 外文期刊>Cell cycle >Resetting gene expression in chronic Chagas heart disease.
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Resetting gene expression in chronic Chagas heart disease.

机译:在慢性恰加斯州心脏病中重置基因表达。

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摘要

Chagas disease is caused by infection with the protozoan parasite Trypanosoma cruzi. Chagas disease does not usually cure spontaneously, but most patients undergo a silent phase, known as indeterminate form, in which chronic infection is not associated with clinical disease. However, in a significant proportion of cases (up to 30%), infection causes heart disease that can be very severe. The major pathological finding in the heart of infected individuals is that of a chronic progressive and fibrosing myocarditis, which causes two major clinical syndromes: heart failure and complex arrhythmias (Dutra et al., 2005). Vaccines are not available, and specific treatment with anti-parasite drugs is recommended during acute infection and is likely to be useful in patients with the indeterminate form of the disease. In patients with severe heart disease, medical treatment of heart failure and arrhythmia is necessary, and heart transplant may be carried out as a last resort.
机译:恰加斯病是由原生动物寄生虫克氏锥虫感染引起的。恰加斯病通常不能自发治愈,但是大多数患者处于沉默期,称为不确定型,在该期中慢性感染与临床疾病无关。但是,在很大比例的案例中(高达30%),感染会导致心脏病,这种疾病可能非常严重。感染者心脏的主要病理发现是慢性进行性和纤维化性心肌炎,它引起两种主要的临床综合征:心力衰竭和复杂性心律不齐(Dutra等,2005)。目前尚无疫苗,建议在急性感染期间使用抗寄生虫药物进行特殊治疗,并且可能对这种不确定形式的患者有用。对于患有严重心脏病的患者,必须进行心力衰竭和心律不齐的医学治疗,并且不得已进行心脏移植。

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