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首页> 外文期刊>Cell Biology and Toxicology >Effect of methanol intoxication on specific immune functions of albino rats.
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Effect of methanol intoxication on specific immune functions of albino rats.

机译：甲醇中毒对白化病大鼠特定免疫功能的影响。

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Our previous studies revealed that methanol intoxication significantly altered the non-specific immune functions in albino rats. The present investigation focuses on the effect of methanol on certain specific immune functions of cell mediated immunity such as footpad thickness, leukocyte migration inhibition test (LMI) and antibody levels. In addition, serum interleukins (IL-2, IL-4, TNF-alpha and IFN-gamma), and splenic lymphocyte subsets were measured after an immune challenge. The specific immune function tests were carried out in three different groups of albino rats, which include control, 15 and 30 days methanol intoxication. Our study reports that animal body weight, organ weight ratio, lymphoid cell counts, footpad thickness, antibody titer, IL-2, TNF-alpha, IFN-gamma, Pan T cell, CD4, macrophages, MHC class II molecule expression, and B cell counts were significantly decreased compared to control animals nevertheless, LMI, IL-4, and DNA single strand breakage were increased significantly. Plasma corticosterone level was significantly increased in the 15 days group whereas the 30 days methanol intoxication group showed considerable decrease in corticosterone level compared with control animals. Therefore, our investigation concluded that repeated exposure of methanol profoundly suppressed the cell mediated and humoral immune functions in albino rats.
机译：我们以前的研究表明，甲醇中毒会明显改变白化病大鼠的非特异性免疫功能。本研究的重点是甲醇对细胞介导的免疫的某些特定免疫功能的影响，例如脚垫厚度，白细胞迁移抑制试验（LMI）和抗体水平。另外，在免疫激发后，测量血清白介素（IL-2，IL-4，TNF-α和IFN-γ）和脾淋巴细胞亚群。在三组不同的白化病大鼠中进行了特异性免疫功能测试，包括对照组，甲醇中毒15天和30天。我们的研究报告动物体重，器官重量比，淋巴样细胞计数，足垫厚度，抗体滴度，IL-2，TNF-alpha，IFN-γ，Pan T细胞，CD4，巨噬细胞，MHC II类分子表达和B然而，与对照动物相比，细胞计数显着减少，LMI，IL-4和DNA单链断裂显着增加。与对照组动物相比，在15天组中血浆皮质酮水平显着增加，而30天甲醇中毒组显示皮质酮水平显着下降。因此，我们的研究得出的结论是，反复暴露于甲醇中可显着抑制白化病大鼠的细胞介导和体液免疫功能。

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