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首页> 外文期刊>Research communications in molecular pathology and pharmacology >Inhibition of platelet activation by quinones isolated from Auxemma oncocalyx Taub.
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Inhibition of platelet activation by quinones isolated from Auxemma oncocalyx Taub.

机译：分离自Auxemma oncocalyx Taub的醌对血小板活化的抑制作用。

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摘要

The present work explored the anti-platelet effect produced by the quinone fractions (17.8, 35.7 and 71.4 microg/ml) isolated from the heartwood of Auxemma oncocalyx Taub. Our results show that the quinone fraction (QF) is a reversible and concentration-dependent inhibitor of human platelet aggregation induced by ADP, arachidonic acid (AA), collagen and thrombin. Besides, the QF effect was significantly potentiated after its association with aspirin or imidazole, and in this case, the AA-induced platelet aggregation was completely blocked. The addition of QF to L-arginine caused a small but significant increase in the percentage of platelet inhibition (13%) only when compared to QF alone. Finally, the addition of QF to pentoxifylline, a known phosphodiesterase inhibitor, resulted in significant potentiation (43% inhibition) of the antiplatelet effects seen with QF (9.7%) or PTX (10%) alone. Although QF presented an antiplatelet effect, it caused a significant decrease in bleeding time, manifested 3 h after oral (100 or 200 mg/Kg) or 1 and 3 h after intraperitonial (30 mg/Kg) administration. In conclusion. QF possibly acts through a combined cyclo-oxygenase and TxA2 synthase inhibition. Besides, QF also increases platelets cAMP levels which also contributes to its anti-aggregatory effects.
机译：本工作探讨了从Auxemma oncocalyx Taub心材中分离的醌级分（17.8、35.7和71.4 microg / ml）产生的抗血小板作用。我们的结果表明，醌级分（QF）是可逆性和浓度依赖性的ADP，花生四烯酸（AA），胶原蛋白和凝血酶诱导的人血小板聚集的抑制剂。此外，与阿司匹林或咪唑结合后，QF效应显着增强，在这种情况下，AA诱导的血小板聚集被完全阻断。仅当与单独的QF相比时，向L-精氨酸中添加QF导致血小板抑制百分比小幅但显着增加（13％）。最后，在己酮可可碱（一种已知的磷酸二酯酶抑制剂）中添加QF，可单独使用QF（9.7％）或PTX（10％）可显着增强抗血小板作用（抑制43％）。尽管QF具有抗血小板作用，但它导致出血时间显着减少，表现为口服（100或200 mg / Kg）后3小时或腹膜内（30 mg / Kg）给药后1和3小时。结论。 QF可能通过组合的环氧合酶和TxA2合酶抑制起作用。此外，QF还增加了血小板的cAMP水平，这也有助于其抗聚集作用。

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