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Cenexin1 and Odf2: Splice variants with diverged cilium functions

机译：Cenexin1和Odf2：具有不同纤毛功能的剪接变体

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The primary cilium is an essential sensory "antenna" jutting from the cell surface of animal cells. Once thought to be a vestigial structure, the cilium has emerged in the last decade as a vital sensory organelle that impacts a broad spectrum of human diseases named ciliopathies.The cilium contains a microtubule-based axoneme composed of nine doublet microtu-bules arranged in a radially symmetric pattern that grows from the distal end of the basal body. The basal body is a modified centriole, a structural component of the centrosome that contains a mother-daughter centriole pair. At ciliogenesis, the mother matures into a basal body for cilium assembly. The mother centriole is distinguished from the daughter by distal and subdistal appendages that are involved in basal body anchoring to the membrane prior to cilium assembly. Loss of Cenexini, a component of the distal appendages, disrupts cilium assembly.1 Therefore, dissecting the components of basal bodies and determining how they work will unravel the molecular mechanisms of ciliogenesis, providing a deeper understanding of ciliopathies.
机译：初级纤毛是从动物细胞的细胞表面突出的基本感觉“天线”。纤毛曾经被认为是一种残留结构，在过去的十年中已成为一种重要的感觉细胞器，影响着广泛的人类疾病，称为纤毛病。纤毛包含一个微管轴突，由九个双峰微管组成，排列在一个小管中。从基体的远端开始生长的径向对称图案。基体是修饰的中心粒，是包含母女中心粒对的中心体的结构成分。在纤毛发生时，母亲成熟成基体，进行纤毛组装。母中心与子中心的区别在于远端和近端附属物，它们与纤毛组装前基体锚定在膜上有关。塞内西尼（远端附件的一个组成部分）的丢失会破坏纤毛的组装。1因此，解剖基体的各个组成部分并确定其工作方式将揭示纤毛发生的分子机制，从而使人们对纤毛病有更深入的了解。

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