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首页> 外文期刊>Cell cycle >Interchanging heads: p53 re-composes the DREAM/MMB complex to repress transcription
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Interchanging heads: p53 re-composes the DREAM/MMB complex to repress transcription

机译：互换头：p53重组DREAM / MMB复合物以抑制转录

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摘要

In the popular tale "Ozma of Oz," Lyman Frank Baum describes the princess Langwidere, who is capable of interchanging her currently worn head with another one, using a collection of heads stored in a cabinet. Remarkably, she changes her character as well when putting a new head on her neck. In the December 15, 2012 issue of Cell Cycle, Kurt Engeland and colleagues report a similar phenomenon1 with regard to a DNA-associated, transcription-regulatory complex of proteins, the DREAM/MMB complex. A central core of this complex, MuvB, binds to a DNA motif called CHR for cell cycle genes homology region. In addition, the complex has facultative members. Either the B-Myb oncoprotein joins to activate transcription from the adjacent gene-this composition is termed MMB for Myb-MuvB. Alternatively, the retinoblastoma protein homolog p130, along with the prototype-repressive member of the E2F family, E2F4 and the auxiliary DNA-binding partner protein DP1, associate with MuvB to form an entity called DREAM for DP, RB-like, E2F and MuvB complex, This complex was first purified from Drosophila embryos
机译：莱曼·弗兰克·鲍姆（Lyman Frank Baum）在流行的故事《绿野仙踪》中描述了公主兰德威德，她可以使用存储在橱柜中的多个头部将她目前佩戴的头部与另一个头部互换。值得注意的是，当将新的头部戴在脖子上时，她也改变了自己的性格。在2012年12月15日的《细胞周期》杂志上，Kurt Engeland及其同事报道了一种与DNA相关的蛋白质转录调控复合物DREAM / MMB复合体类似的现象1。该复合物的中心核心MuvB与细胞周期基因同源性区域的称为CHR的DNA基序结合。此外，综合大楼还设有兼职成员。 B-Myb癌蛋白都可以激活邻近基因的转录-这种成分被称为Myb-MuvB的MMB。或者，视网膜母细胞瘤蛋白同源物p130以及E2F家族的原型抑制成员E2F4和辅助DNA结合伴侣蛋白DP1与MuvB结合形成称为DPREA，RB-like，E2F和MuvB的实体复合物，首先从果蝇胚胎中纯化

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