Dma/RNF8 proteins are evolutionarily conserved 3 ubiquitin ligases that target septins

ChahwanR.; GravelS.; MatsusakaT.; JacksonS.P.

首页> 外文期刊>Cell cycle >Dma/RNF8 proteins are evolutionarily conserved 3 ubiquitin ligases that target septins

【24h】

Dma/RNF8 proteins are evolutionarily conserved 3 ubiquitin ligases that target septins

机译：Dma / RNF8蛋白是进化上保守的3个针对septins的泛素连接酶

获取原文

获取原文并翻译 | 示例

掌桥外文数据库（机构版） >>

开具论文收录证明 >>

文献代查 >>

页面导航

摘要
著录项
相似文献
相关主题

摘要

The budding yeast proteins Dma1 and Dma2 are members of the unique FHA-RING domain protein family and are linked to mitotic regulation and septin organization by ill-defined mechanisms. We show that Dma2 has ubiquitin ligase activity, and that septins Shs1 and Cdc11 are likely direct in vivo targets. We further propose that human RNF8, rather than Chfr, is the mammalian Dma homolog. As in yeast, RNF8 localizes to the centrosomes and cell division sites and promotes ubiquitylation of the septin SEPT 7, whose depletion increases cell division anomalies. Together, these findings reveal evolutionary and functional conservation of Dma proteins, and suggest that RNF8 maintains genome stability through independent, yet analogous, nuclear and cytoplasmic ubiquitylation activities.

机译：出芽的酵母蛋白Dma1和Dma2是独特的FHA-RING结构域蛋白家族的成员，并通过不明确的机制与有丝分裂调控和Septin组织相关。我们显示Dma2具有泛素连接酶活性，并且Septins Shs1和Cdc11可能是直接体内靶标。我们进一步提出，人RNF8而不是Chfr是哺乳动物Dma同源物。与酵母中一样，RNF8定位于中心体和细胞分裂位点，并促进septin SEPT 7的泛素化，其耗尽会增加细胞分裂异常。总之，这些发现揭示了Dma蛋白的进化和功能保守性，并表明RNF8通过独立但相似的核和细胞质泛素化活性来维持基因组稳定性。

著录项

来源
《Cell cycle》 |2013年第6期|共9页
作者
ChahwanR.; GravelS.; MatsusakaT.; JacksonS.P.;
展开▼
作者单位

展开▼
收录信息
原文格式 PDF
正文语种 eng
中图分类细胞生物学;
关键词
Chfr; Cytokinesis; Dma1; Dma2; E3 ubiquitin ligase; Midbody; RNF8; Septin-ring; Septins; Ubiquitin;

机译：Chfr;细胞分裂;Dma1;Dma2;E3泛素连接酶;中体;RNF8;Septin环;Septins;泛素;

相似文献

外文文献
中文文献
专利

1. Dma/RNF8 proteins are evolutionarily conserved 3 ubiquitin ligases that target septins [J] . ChahwanR., GravelS., MatsusakaT., Cell cycle . 2013,第6期

机译：Dma / RNF8蛋白是进化上保守的3个针对septins的泛素连接酶
2. Role of WW domain E3 ubiquitin protein ligase 2 in modulating ubiquitination and Degradation of Septin4 in oxidative stress endothelial injury [J] . Naijin Zhang, Ying Zhang, Boquan Wu, Redox Biology . 2020,第3期

机译：WW结构域E3泛素蛋白连接酶2在调节氧化应激内皮损伤中调节枯草4的ubiquitination和降解的作用
3. Drosophila melanogaster Parkin ubiquitinates peanut and septin1 as an E3 ubiquitin-protein ligase [J] . Bae YJ, Kang SJ, Park KS Insect Biochemistry and Molecular Biology . 2007,第5期

机译：果蝇黑色素激酶泛素化花生和septin1作为E3泛素蛋白连接酶。
4. Regulation of the HIF pathway: enzymatic hydroxylation of a conserved prolyl residue inhypoxia-inducible factor alpha subunits governs capture by the pVHL E3 ubiquitin ligase complex [C] . David R. Mole, Christopher W. Pugh, Peter J. Ratcliffe, International Symposium on Regulation of Enzyme Activity and Synthesis in Normal and Neoplastic Tissues . 2003

机译：HIF途径的调节：保守脯氨酰残基的酶促羟基化inhypymoxia-Invucient因子α亚基治理PVHL E3泛素连接酶复合物捕获
5. Nitric oxide and protein ubiquitination: Discovery and characterization of the E3 ubiquitin ligase RNF25 as a target of nitric oxide [D] . Wille, Pamela Christine. 2013

机译：一氧化氮和蛋白质泛素化：发现和表征E3泛素连接酶RNF25作为一氧化氮的靶标
6. Dma/RNF8 proteins are evolutionarily conserved E3 ubiquitin ligases that target septins [O] . Richard Chahwan, Serge Gravel, Takahiro Matsusaka, 2013

机译：Dma / RNF8蛋白是进化上保守的E3泛素连接酶靶向Septins
7. Dma/RNF8 proteins are evolutionarily conserved E3 ubiquitin ligases that target septins. [O] . Chahwan, R, Gravel, S, Matsusaka, T, 2016

机译：Dma / RNF8蛋白是靶向septins的进化保守的E3泛素连接酶。

Dma/RNF8 proteins are evolutionarily conserved 3 ubiquitin ligases that target septins

摘要

著录项

相似文献

相关主题

期刊订阅