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首页> 外文期刊>Cell cycle >Many fingers on the mitotic trigger: post-translational regulation of the Cdc25C phosphatase.
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Many fingers on the mitotic trigger: post-translational regulation of the Cdc25C phosphatase.

机译：有丝分裂触发的许多手指：Cdc25C磷酸酶的翻译后调控。

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摘要

The mitotic inducer Cdc25 phosphatase controls the activation of Cdc2/cyclin B protein kinase and entry into mitosis in eukaryotic cells. Cdc25C is highly regulated by multiple post-translational modifications within its N-terminal regulatory domain and site-specific protein interactions. Phosphorylation of one inhibitory site targeted by multiple kinases determines the timing of Cdc25C activation and arrests cells in G2 in response to checkpoint, stress, developmental and extracellular signals. In mitosis, phosphorylation of several Ser/Thr residues and Pin1-catalysed peptidyl-proline isomerisation produces activation. Phosphorylation of one activating site is antagonistic to the proximal inhibitory site and maintains Cdc25C activity during mitosis. Phosphorylation and interacting proteins also modulate the nuclear import and export signals on Cdc25C, inducing dramatic changes in its localisation within the cell. Thus, the regulation of Cdc25C activity and localization integrates multiple signals thatgovern the decision to enter mitosis.
机译：有丝分裂诱导剂Cdc25磷酸酶控制Cdc2 / cyclin B蛋白激酶的激活并进入真核细胞中的有丝分裂。 Cdc25C在其N末端调节域内的多个翻译后修饰和位点特异性蛋白质相互作用中受到高度调节。多种激酶靶向的一个抑制位点的磷酸化决定了Cdc25C活化的时机，并响应检查点，压力，发育和细胞外信号而使G2细胞停滞。在有丝分裂中，几个Ser / Thr残基的磷酸化和Pin1催化的肽基脯氨酸异构化会产生活化。一个激活位点的磷酸化拮抗近端抑制位点，并在有丝分裂过程中保持Cdc25C活性。磷酸化和相互作用的蛋白质还调节Cdc25C上的核进出口信号，从而诱导其在细胞内的定位发生巨大变化。因此，对Cdc25C活性和定位的调节整合了控制进入有丝分裂决定的多种信号。

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