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p63, cell adhesion and survival.

机译:p63,细胞粘附和存活。

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The development of stratified epithelia and their derivatives is a complex process requiring a multifaceted transcriptional program. p63, the p53-related transcription factor, is fundamental to this process. However, the underlying mechanisms by which p63 exerts its influence on stratified epithelial development and integrity remain elusive. Recent work from our laboratories has demonstrated that p63 mediates its effects on stratified epithelial function at least in part via its ability to regulate multiple aspects of epithelial cellular adhesion and survival. The identification of cell-cell and cell-matrix adhesion subprograms downstream of p63 provides an initial understanding of p63's role in epithelial development, integrity and homeostasis.
机译:分层上皮及其衍生物的发展是一个复杂的过程,需要多方面的转录程序。 p63,p53相关的转录因子,是此过程的基础。但是,p63对分层的上皮发育和完整性施加影响的潜在机制仍然难以捉摸。我们实验室的最新研究表明,p63至少部分地通过调节上皮细胞粘附和存活的多个方面来介导其对分层上皮功能的影响。对p63下游的细胞-细胞和细胞-基质粘附子程序的鉴定提供了对p63在上皮发育,完整性和体内稳态中作用的初步了解。

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