DNA damage leaves its mark on chromatin.

Polo SE; Almouzni G

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DNA damage leaves its mark on chromatin.

机译：DNA损伤在染色质上留下痕迹。

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DNA organization into chromatin has a major influence on the cellular response to DNA damage. Recent studies in various systems ranging from yeast to human cells stress the importance of chromatin not simply as a barrier to DNA repair processes but also as an active contributor to the DNA damage response. Indeed, modulations of chromatin organization involving various degrees of rearrangements, such as histone modifications and even nucleosome displacement, can promote efficient repair and also participate in checkpoint signaling. Here, we survey recent progress in delineating how chromatin rearrangements provide crosstalk with the DNA damage response. In particular, we highlight new data on histone dynamics at damage sites and discuss their functional importance for the stable propagation of specific chromatin states.

机译：将DNA组织成染色质对细胞对DNA损伤的反应具有重要影响。从酵母到人类细胞，各种系统的最新研究都强调了染色质的重要性，其不仅是DNA修复过程的障碍，而且还是DNA损伤反应的积极贡献者。实际上，涉及各种程度的重排的染色质组织调节，例如组蛋白修饰，甚至核小体置换，都可以促进有效修复，并参与检查点信号传导。在这里，我们调查了在描绘染色质重排如何与DNA损伤反应提供串扰方面的最新进展。特别是，我们重点介绍了损伤部位组蛋白动力学的新数据，并讨论了它们对于特定染色质状态稳定传播的功能重要性。

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《Cell cycle》 |2007年第19期|共5页
作者
Polo SE; Almouzni G;
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正文语种 eng
中图分类细胞生物学;
关键词
Animals; Chromatin; Chromosomes; DNA Damage; DNA Repair; Histones; Humans; 动物; 染色质; 染色体; DNA损伤; DNA修复; 组蛋白类; 核小体; 紫外线;

机译：Animals;Chromatin;Chromosomes;DNA Damage;DNA Repair;Histones;Humans;动物;染色质;染色体;DNA损伤;DNA修复;组蛋白类;核小体;紫外线;

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1. DNA damage leaves its mark on chromatin. [J] . Polo SE, Almouzni G Cell cycle . 2007,第19期

机译：DNA损伤在染色质上留下痕迹。
2. Cadmium induces DNA damage in tobacco roots, but no DNA damage, somatic mutations or homologous recombination in tobacco leaves. [J] . Gichner T, Patkova Z, Szakova J, Mutation Research: International Journal on Mutagenesis, Chromosome Breakage and Related Subjects . 2004,第1a2期

机译：镉在烟根中诱导DNA损伤，但在烟叶中不引起DNA损伤，体细胞突变或同源重组。
3. The Mechanisms of Oxidative Damage-Induced Localization of Mismatch Repair Protein Heterodimer MSH2-MSH6 and Epigenetic Protein DNA Methyltransferase 1 to Chromatin. [J] . Ding N., Bonham E. M., Hannon B. E., Environmental and molecular mutagenesis. . 2016,第Suppla1期

机译：氧化损伤诱导定位的错配修复蛋白异二聚体MSH2-MSH6和表观遗传蛋白DNA甲基转移酶1至染色质的机制。
4. Reducing the Level of Leaves Damage of (Brassica rapa) Caused by Armyworm (Spodoptera litura F.) Through Liquid Bioinsecticide Formulation of Bintaro (Cerbera odollam) Leaves Extract [C] . Kristanti Indah Purwani, Sri Nurhatika, Dini Ermavitalini, International Biology Conference . 2017

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5. Spatial rape: Globalization and the tourist-vagabond relationship in Mark Z. Danielewski's "House of Leaves" [D] . Stephens, Tracy. 2010

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6. Studies on rat liver nuclear DNA damaged by chemical carcinogen (3-Me DAB) and AP DNA endonuclease. I. Purification and some properties of AP DNA endonucleases in rat liver chromatin. [O] . Y. S. Kim, J. W. Kim, S. E. Lee, 1990

机译：化学致癌物（3-Me DAB）和AP DNA核酸内切酶对大鼠肝核DNA的研究。 I.大鼠肝染色质中AP DNA核酸内切酶的纯化和某些特性。
7. Studies on rat liver nuclear DNA damaged by chemical carcinogen (3'-Me DAB) and AP DNA endonuclease. I. Purification and some properties of AP DNA endonucleases in rat liver chromatin. [O] . Kim, Y. S., Kim, J. W., Lee, S. E., 1990

机译：化学致癌物（3'-Me DAB）和AP DNA核酸内切酶对大鼠肝核DNA的研究。 I.大鼠肝染色质中AP DNA核酸内切酶的纯化和某些性质。

DNA damage leaves its mark on chromatin.

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