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首页> 外文期刊>Cell cycle >Function of cyclins in regulating the mitotic and meiotic cell cycles in male germ cells.
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Function of cyclins in regulating the mitotic and meiotic cell cycles in male germ cells.

机译：细胞周期蛋白在调节雄性生殖细胞中有丝分裂和减数分裂细胞周期中的功能。

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摘要

The specialized cell cycles that characterize various aspects of the differentiation of germ cells provide a unique opportunity to understand heretofore elusive aspects of the in vivo function of cell cycle regulators. Key components of the cell cycle machinery are the regulatory sub-units, the cyclins, and their catalytic partners, the cyclin-dependent kinases. Some of the cyclins exhibit unique patterns of expression in germ cells that suggest possible concomitant distinct functions, predictions that are being explored by targeted mutagenesis in mouse models. A novel, meiosis-specific function has been shown for one of the A-type cyclins, cyclin A1. Embryonic lethality has obviated understanding of the germline functions of cyclin A2 and cyclin B1, while yet other cyclins, although expressed at specific stages of germ cell development, may have less essential function in the male germline.
机译：表征生殖细胞分化各个方面的专门细胞周期提供了一个独特的机会，以了解迄今难以捉摸的细胞周期调节因子体内功能方面。细胞周期机制的关键组成部分是调节亚基，细胞周期蛋白及其催化伙伴，细胞周期蛋白依赖性激酶。一些细胞周期蛋白在生殖细胞中表现出独特的表达模式，提示可能伴随的独特功能，这些预测已通过小鼠模型中的定向诱变进行了探索。对于一种A型细胞周期蛋白，细胞周期蛋白A1，已显示出一种新的减数分裂特异功能。胚胎致死性消除了对细胞周期蛋白A2和细胞周期蛋白B1的生殖细胞功能的了解，而其他细胞周期蛋白尽管在生殖细胞发育的特定阶段表达，但在雄性生殖细胞中的基本功能可能较少。

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