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What's New in Tight Junctions: A Report on the 2002 ASCB Meeting, San Francisco, CA

机译:紧密连接的新功能:2002年ASCB会议报告,加利福尼亚州旧金山

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摘要

Tight junctions(TJ) seal the apicolateral border of epithelial and endothelial cells, and control the diffusion of ions, molecules and cells through the space between cells ("barrier" function). Thus, TJ are responsible for the establishment and maintenance of compartments within organs, and allow epithelia to maintain ionic and molecular gradients crucial for a variety of important physiological processes, including sensation, absorption, secretion, and protection from pathogens. In addition, TJ define the border between apical and basolateral plasma membrane domains ("fence" function), and thus are a hallmark of polarized epithelial cells (Figure 1A and 1B).
机译:紧密连接(TJ)密封上皮和内皮细胞的顶侧边界,并控制离子,分子和细胞通过细胞之间的空间扩散(“屏障”功能)。因此,TJ负责器官内隔室的建立和维持,并允许上皮细胞维持对多种重要生理过程(包括感觉,吸收,分泌和对病原体的防护)至关重要的离子和分子梯度。此外,TJ定义了顶端和基底外侧质膜域之间的边界(“围栏”功能),因此是极化上皮细胞的标志(图1A和1B)。

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