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首页> 外文期刊>Cell communication & adhesion >Metastatic Properties of Prostate Cancer Cells are Controlled by VEGF
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Metastatic Properties of Prostate Cancer Cells are Controlled by VEGF

机译：前列腺癌细胞的转移特性受VEGF控制

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Mechanisms of metastasis, the major complication of prostate cancer, are poorly understood. In this study, we define molecular mechanisms that may contribute to the highly invasive potential of prostate cancer cells. Vascular endothelial growth factor (VEGF), its receptors (VEGFRs), and α_5β_1 integrin were expressed by prostate cancer cells in vitro and by prostate tumors in vivo, and their expression was elevated at sites of bone metastasis compared to original prostate tumor. VEGF, through interaction with its receptors, regulated adhesive and migratory properties of the cancer cells. Specifically, the highly metastatic prostate cancer cell subline LNCaP-C4-2 showed a decreased adhesive but an enhanced migratory response to fibronectin, a ligand for α_5β_1 integrin, compared to its nonmetastatic counterpart. A similar pattern was also observed when bone sialoprotein was used as a ligand in migration assays. Increased migration of metastatic prostate cancer cells to fibronectin and bone sialoprotein was regulated by VEGF via VEGFR-2. Tumor suppressor PTEN was involved in control of VEGF/VEGFR-2 stimulated prostate cancer cell adhesion as well as proliferation.
机译：转移的机制，前列腺癌的主要并发症，了解甚少。在这项研究中，我们定义了可能有助于前列腺癌细胞高度侵袭性的分子机制。血管内皮生长因子（VEGF），其受体（VEGFRs）和α_5β_1整联蛋白在体外由前列腺癌细胞表达，在体内由前列腺肿瘤表达，与原始前列腺肿瘤相比，它们在骨转移部位的表达升高。 VEGF通过与其受体相互作用，调节癌细胞的黏附和迁移特性。具体而言，与非转移性对应物相比，高度转移性前列腺癌细胞亚系LNCaP-C4-2显示出减少的黏附但增强了对纤连蛋白（α_5β_1整联蛋白的配体）的迁移反应。当骨唾液蛋白用作迁移测定中的配体时，也观察到类似的模式。 VEGF经由VEGFR-2调节转移性前列腺癌细胞向纤连蛋白和骨唾液蛋白迁移的增加。抑癌基因PTEN参与了VEGF / VEGFR-2刺激的前列腺癌细胞粘附和增殖的控制。

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