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首页> 外文期刊>Biological & pharmaceutical bulletin >The protective effects of piceatannol from passion fruit (Passiflora edulis) seeds in UVB-irradiated keratinocytes
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The protective effects of piceatannol from passion fruit (Passiflora edulis) seeds in UVB-irradiated keratinocytes

机译：百香果（Passiflora edulis）种子中的苦味酚对紫外线B照射的角质形成细胞的保护作用

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摘要

The use of naturally occurring botanicals with substantial antioxidant activity to prevent photoageing is receiving increasing attention. We have previously identified piceatannol and scirpusin B, which is a dimer of piceatannol, as strong antioxidants that are present in passion fruit (Passiflora edulis) seeds. In the present study, the effects of passion fruit seed extract, piceatannol, and scirpusin B on human keratinocytes were investigated. The passion fruit seed extract and piceatannol upregulated the glutathione (GSH) levels in keratinocytes in a dose-dependent manner, indicating that piceatannol is an active component of the passion fruit seed extract in keratinocytes. The pretreatment with piceatannol also supressed the UVB-induced generation of reactive oxygen species (ROS) in the keratinocytes. In addition, the transfer of the medium from the UVB-irradiated keratinocytes to non-irradiated fibroblasts enhanced matrix-metalloproteinase (MMP)-1 activity, and this MMP-1 induction was reduced when the keratinocytes were pretreated with piceatannol. These results suggest that piceatannol attenuates the UVB-induced activity of MMP-1 along with a reduction of ROS generation in keratinocytes. Thus, piceatannol and passion fruit seed extract containing high amounts of piceatannol are potential anti-photoageing cosmetic ingredients.
机译：具有重要抗氧化剂活性的天然植物药的使用防止光老化已受到越来越多的关注。我们之前已经鉴定出Piceatannol和Sirpusin B是Piceatannol的二聚体，它是百香果（Passiflora edulis）种子中存在的强抗氧化剂。在本研究中，研究了百香果种子提取物，皮卡坦酚和鞘氨醇B对人角质形成细胞的作用。百香果种子提取物和苦瓜粉醇以剂量依赖的方式上调了角质形成细胞中谷胱甘肽（GSH）的水平，表明苦橙子醇是百香果种子提取物中角质形成细胞的活性成分。用皮卡替诺醇进行的预处理还抑制了UVB诱导的角质形成细胞中活性氧（ROS）的生成。此外，培养基从UVB照射的角质形成细胞向未照射的成纤维细胞的转移增强了基质金属蛋白酶（MMP）-1的活性，而当用角叉菜醇预处理角质形成细胞时，这种MMP-1诱导作用降低。这些结果表明，皮卡替诺醇可减弱UVB诱导的MMP-1活性，并减少角质形成细胞中ROS的产生。因此，含有大量苦味酚的苦味酚和百香果种子提取物是潜在的抗光老化化妆品成分。

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