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首页> 外文期刊>Biological Theory: integrating development, evolution & cognition >Cancer Ecology: Niche Construction, Keystone Species, Ecological Succession, and Ergodic Theory
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Cancer Ecology: Niche Construction, Keystone Species, Ecological Succession, and Ergodic Theory

机译：癌症生态学：生态位构建，关键物种，生态演替和遍历理论

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摘要

Parallels between cancer and ecological systems have been increasingly recognized and extensively reviewed. However, a more unified framework of understanding cancer as an evolving dynamical system that undergoes a sequence of interconnected changes over time, from a dormant microtumor to disseminated metastatic disease, still needs to be developed. Here, we focus on several examples of such mechanisms, namely, how in cancer niche construction a metabolic adaptation and consequent change to the tumormicroenvironment (niche modification) becomes an important factor in evasion of the predator (immune system), facilitating disease progression; how tumor establishment and propagation is driven by the tumor's own keystone species, the cancer stem cells;and how the succession of stages of metastatic dissemination can be informed by ergodic theory and forest ecology.
机译：癌症与生态系统之间的平行性已得到越来越多的认可和广泛审查。但是，仍然需要建立一个更加统一的框架，将癌症理解为不断发展的动力系统，该系统会随着时间的推移而发生一系列相互联系的变化，从休眠的微肿瘤到弥漫性转移性疾病。在这里，我们关注这些机制的几个例子，即在癌症生态位构建中，代谢适应和随之而来的肿瘤微环境变化（生态位修饰）如何成为逃避掠食者（免疫系统），促进疾病进展的重要因素;如何通过肿瘤自身的主要结石物种，癌症干细胞驱动肿瘤的建立和传播;以及如何通过遍历理论和森林生态学了解转移扩散阶段的顺序。

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