...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Biological Theory: integrating development, evolution & cognition >Evolution of the Genetic Code: The Ribosome-Oriented Model
【24h】

Evolution of the Genetic Code: The Ribosome-Oriented Model

机译：遗传密码的进化：面向核糖体的模型

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

There are currently three major theories on the origin and evolution of the genetic code: the stereochemical theory, the coevolution theory, and the error-minimization theory. The first two assume that the genetic code originated respectively from chemical affinities and from metabolic relationships between codons and amino acids. The error-minimization theory maintains that in primitive systems the apparatus of protein synthesis was extremely prone to errors, and postulates that the genetic code evolved in order to minimize the deleterious effects of the translation errors. This article describes a fourth theory which starts from the hypothesis that the ancestral genetic code was ambiguous and proposes that its evolution took place with a mechanism that systematically reduced its ambiguity and eventually removed it altogether. This proposal is distinct from the stereochemical and the coevolution theories because they do not contemplate any ambiguity in the genetic code, and it is distinct from the error-minimization theory because ambiguity-reduction is fundamentally different from error-minimization. The concept of ambiguity-reduction has been repeatedly mentioned in the scientific literature, but so far it has remained only an abstract possibility because no model has been proposed for its mechanism. Such a model is described in the present article and may be the first step in a new approach to the study of the evolution of the genetic code.
机译：关于遗传密码的起源和进化，目前存在三种主要理论：立体化学理论，协同进化理论和误差最小化理论。前两个假设遗传密码分别源自化学亲和力和密码子与氨基酸之间的代谢关系。最小化错误的理论认为，在原始系统中，蛋白质合成的设备极易出现错误，并假设遗传密码已进化出来，以最大程度地减少翻译错误的有害影响。本文介绍了第四个理论，该理论从祖先的遗传密码模棱两可这一假设出发，并提出其进化是通过一种机制来系统地降低其歧义性并最终将其彻底消除的。该提议不同于立体化学和协同进化理论，因为它们没有考虑遗传密码中的任何歧义，并且不同于误差最小化理论，因为减少歧义性与误差最小化根本不同。减少歧义性的概​​念在科学文献中已被反复提及，但到目前为止，由于它的机理尚未提出任何模型，因此它仅是一种抽象的可能性。本文中描述了这种模型，这可能是研究遗传密码进化的新方法的第一步。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号