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p63: a new link between senescence and aging.

机译:p63:衰老与衰老之间的新联系。

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Cellular senescence is a distinctive form of cell cycle arrest that has been suggested to modulate the processes of tumor suppression and aging. Though a detailed understanding of the cellular machinery regulating this process is emerging, a more thorough understanding of the key players linking senescence to organismal aging is needed. The recent discovery that loss of the p53-related protein p63 induces cellular senescence and causes features of accelerated aging provides further evidence that cellular senescence is intimately linked with organismal aging, and identifies p63 as a key regulator of both of these processes.
机译:细胞衰老是细胞周期停滞的一种独特形式,已被认为可调节肿瘤抑制和衰老过程。尽管对调节该过程的细胞机制的详细了解正在出现,但仍需要对将衰老与机体衰老联系起来的关键因素的更透彻理解。最近发现p53相关蛋白p63的缺失会诱导细胞衰老并引起加速衰老的特征,这提供了进一步的证据,证明细胞衰老与机体衰老密切相关,并将p63识别为这两个过程的关键调节因子。

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