Identification of novel ARF binding proteins by two-hybrid screening.

Tompkins V; Hagen J; Zediak VP; Quelle DE

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Identification of novel ARF binding proteins by two-hybrid screening.

机译：通过两杂交筛选鉴定新型ARF结合蛋白。

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The ARF tumor suppressor protects us against cancer through protein-protein interactions in partially defined p53-dependent and p53-independent pathways. We performed a two-hybrid screen using ARF as bait and present the identification of several new ARF partners that may regulate its growth inhibitory signaling. The potential physiological roles of these novel ARF binding proteins in regulating ARF signaling are discussed.

机译：ARF抑癌药通过部分定义的p53依赖性和p53依赖性途径中的蛋白质相互作用来保护我们免受癌症侵害。我们使用ARF作为诱饵进行了两次杂交筛选，并提出了一些可能调节其生长抑制信号的新ARF伙伴的鉴定。讨论了这些新型ARF结合蛋白在调节ARF信号传导中的潜在生理作用。

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《Cell cycle》 |2006年第6期|共6页
作者
Tompkins V; Hagen J; Zediak VP; Quelle DE;
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正文语种 eng
中图分类细胞生物学;
关键词
Carrier Proteins; Growth Inhibitors; Signal Transduction; Tumor Suppressor Protein p14ARF; 载体蛋白质类; 生长抑制物; 信号传递;

机译：Carrier Proteins;Growth Inhibitors;Signal Transduction;Tumor Suppressor Protein p14ARF;载体蛋白质类;生长抑制物;信号传递;

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1. Identification of novel ARF binding proteins by two-hybrid screening. [J] . Tompkins V, Hagen J, Zediak VP, Cell cycle . 2006,第6期

机译：通过两杂交筛选鉴定新型ARF结合蛋白。
2. HAMS: High-Affinity Mass Spectrometry Screening. A High-Throughput Screening Method for Identifying the Tightest-Binding Lead Compounds for Target Proteins with No False Positive Identifications [J] . Imaduwage Kasun P., Go Eden P., Zhu Zhikai, Journal of the American Society for Mass Spectrometry . 2016,第11期

机译：HAMS：高亲和力质谱筛查。一种高通量筛选方法，用于鉴定目标蛋白的最紧密结合的前导化合物，而没有错误的阳性鉴定
3. Yeast two-hybrid analysis of the origin recognition complex of Saccharomyces cerevisiae: interaction between subunits and identification of binding proteins [J] . Matsuda K, Makise M, Sueyasu Y, FEMS Yeast Research . 2007,第8期

机译：酿酒酵母起源识别复合物的酵母两杂交分析：亚基之间的相互作用和结合蛋白的鉴定
4. Identification of GHB-binding Proteins by Mass Spectrometry - (Chemo)proteomic Analysis of Synaptosomal Membrane Proteins [C] . Ulrike Leurs, Claus H. Jensen, Bente Frolund, ASMS Conference on Mass Spectrometry and Allied Topics . 2016

机译：突触体膜蛋白质谱法鉴定GHB结合蛋白 - （化学）突触体膜蛋白蛋白质组学分析
5. Identification of novel Ras p21-interacting proteins using yeast two-hybrid analysis. [D] . Sarfraz, Yasmeen. 2009

机译：使用酵母双杂交分析鉴定与Ras p21相互作用的新型蛋白。
6. HAMS: High-Affinity Mass Spectrometry Screening. A high-throughput screening method for identifying the tightest-binding lead compounds for target proteins with no false positive identifications [O] . Kasun P. Imaduwage, Eden P. Go, Zhikai Zhu, -1

机译：HAMS：高亲和力质谱筛查。一种高通量筛选方法用于鉴定目标蛋白结合最紧密的先导化合物无假阳性结果
7. Identification of an in vivo orally active dual-binding protein-protein interaction inhibitor targeting TNFα through combined in silico/in vitro/in vivo screening. [O] . Mouhsine, Hadley, Guillemain, Hélène, Moreau, Gabriel, 2017

机译：通过计算机/体外/体内联合筛选，鉴定靶向TNFα的体内口服活性双重结合蛋白-蛋白相互作用抑制剂。

Identification of novel ARF binding proteins by two-hybrid screening.

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