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首页> 外文期刊>Cell cycle >An emerging role for Ca2+/calcineurin/NFAT signaling in cancerogenesis.
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An emerging role for Ca2+/calcineurin/NFAT signaling in cancerogenesis.

机译：Ca2 + /钙调神经磷酸酶/ NFAT信号传导在癌症发生中的新兴作用。

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摘要

The NFAT proteins are a family of Ca2+/calcineurin-responsive transcription factors primarily recognized for their central roles in T lymphocyte activation. Recent studies, however, have demonstrated that the vital role of NFAT signaling is by no means restricted to the immune system. NFAT proteins are potent mediators of Ca2+ signals in many mammalian cells and tissues and control, among others, important steps in myogenesis, chondrocyte differentiation and the development of the cardiovascular system. Owing to the broad spectrum of target genes and the fundamental nature of the cellular processes they control, it comes as no surprise that NFAT proteins are increasingly being recognized as central players in the development of a number of very different human malignancies.
机译：NFAT蛋白是Ca2 + /钙调神经磷酸酶响应转录因子家族，主要因其在T淋巴细胞活化中的核心作用而被认可。但是，最近的研究表明，NFAT信号的重要作用决不限于免疫系统。 NFAT蛋白是许多哺乳动物细胞和组织中Ca2 +信号的有效介体，并控制着成肌，软骨细胞分化和心血管系统发育等重要步骤。由于靶基因的广泛范围和它们控制的细胞过程的基本性质，毫不奇怪，NFAT蛋白在许多非常不同的人类恶性肿瘤的发展中被越来越多地视为主要角色。

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