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首页> 外文期刊>Reproductive biomedicine online >Effect of HCG-day serum progesterone and oestradiol concentrations on pregnancy outcomes in GnRH agonist cycles
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Effect of HCG-day serum progesterone and oestradiol concentrations on pregnancy outcomes in GnRH agonist cycles

机译：GnRH激动剂周期中HCG天血清孕酮和雌二醇浓度对妊娠结局的影响

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摘要

This study analysed the relationship between serum progesterone/oestradiol concentrations and IVF pregnancy outcomes in gonadotrophin-releasing hormone agonist protocols. A total of 2921 infertile women undergoing IVF were assigned to four groups according to serum progesterone and oestradiol concentrations on the day of human chorionic gonadotrophin (HCG) administration: group 1 (control) progesterone < 3.34 nmol/l and oestradiol < 19,124 pmol/l; group 2 (high oestradiol); group 3 (high progesterone); group 4 (high progesterone and high oestradiol). Compared with group 1, group 4 had lower clinical pregnancy and live birth rates as well as the highest ectopic pregnancy rate (29.15% versus 45.91%; 18.67% versus 34.34%; 18.10% versus 5.82%; P < 0.05). Group 3 had lower clinical pregnancy and live birth rates per embryo-transfer cycle (29.78% versus 45.91%; 20.28% versus 34.34%, respectively; P < 0.05). Clinical pregnancy rates were similar in frozen-thawed embryo transfers (FET) among the four groups. In conclusion, elevated progesterone was detrimental to live birth rates. High serum oestradiol concentration on HCG day did not affect the IVF pregnancy outcome. In combination with the elevated progesterone, high oestradiol concentrations had a potential negative effect. For these patients, FET should be suggested to improve the pregnancy outcomes. The aim of this study was to analyse the relationship between serum progesterone/oestradiol concentrations and IVF pregnancy outcomes in gonadotrophin-releasing hormone agonist protocols. A total of 2921 infertile women undergoing IVF were assigned to four groups according to their serum progesterone and oestradiol concentrations on the day of human chorionic gonadotrophin (HCG) administration: group 1 (control) progesterone < 3.34 nmol/l and oestradiol < 19,124 pmol/l; group 2 (high oestradiol); group 3 (high progesterone); group 4 (high progesterone and high oestradiol). Compared with group 1, patients in group 4 had lower clinical pregnancy (29.15% versus 45.91%) and live birth rates (18.67% versus 34.34%) as well as the highest ectopic pregnancy rate (18.1% versus 5.82%) (all P < 0.05). Those in group 3 had lower clinical pregnancy and live birth rates per embryo transfer cycle (29.78% versus 45.91%; 20.28% versus 34.34%, respectively, P < 0.05). Embryo quality appeared to be unaffected since similar clinical pregnancy rates in frozen-thawed embryo transfer (FET) cycles among the four groups. In conclusion, elevated progesterone was detrimental to live birth rates. A high serum oestradiol concentration on the day of HCG administration did not affect the IVF pregnancy outcome. In combination with the elevated progesterone and oestradiol concentrations had a potential negative effect. For these patients, FET should be suggested to improve the pregnancy outcomes.
机译：这项研究分析了促性腺激素释放激素激动剂方案中血清孕酮/雌二醇浓度与IVF妊娠结局之间的关系。根据人绒毛膜促性腺激素（HCG）给药当天的血清孕酮和雌二醇浓度，将总共2921名接受IVF的不育妇女分为四组：第1组（对照）孕酮<3.34 nmol / l和雌二醇<19,124 pmol / l ;第2组（高雌二醇）;第三组（高孕酮）;第4组（高孕酮和高雌二醇）。与第1组相比，第4组的临床妊娠和活产率较低，异位妊娠率最高（29.15％对45.91％; 18.67％对34.34％; 18.10％对5.82％; P <0.05）。第三组的每个胚胎移植周期的临床妊娠率和活产率较低（分别为29.78％对45.91％; 20.28％对34.34％; P <0.05）。四组冷冻融化胚胎移植（FET）的临床妊娠率相似。总之，黄体酮升高对活产率有害。 HCG日血清雌二醇浓度高不会影响IVF妊娠结局。与高水平的孕酮结合使用，高雌二醇浓度有潜在的负面影响。对于这些患者，应建议使用FET改善妊娠结局。这项研究的目的是分析促性腺激素释放激素激动剂方案中血清孕酮/雌二醇浓度与IVF妊娠结局之间的关系。根据人类绒毛膜促性腺激素（HCG）给药当天的血清孕激素和雌二醇浓度，将总共2921名接受IVF的不育妇女分为四组：第1组（对照）孕激素<3.34 nmol / l和雌二醇<19,124 pmol / l;第2组（高雌二醇）;第三组（高孕酮）;第4组（高孕酮和高雌二醇）。与第1组相比，第4组患者的临床妊娠率较低（29.15％对45.91％）和活产率（18.67％对34.34％）以及异位妊娠率最高（18.1％对5.82％）（所有P < 0.05）。第三组中的每个胚胎移植周期的临床妊娠和活产率较低（分别为29.78％对45.91％; 20.28％对34.34％，P <0.05）。胚胎质量似乎没有受到影响，因为四组之间的冻融胚胎移植（FET）周期中的临床妊娠率相似。总之，黄体酮升高对活产率有害。服用HCG当天的血清雌二醇浓度较高，并不影响IVF妊娠结局。与升高的孕酮和雌二醇浓度结合使用具有潜在的负面影响。对于这些患者，应建议使用FET改善妊娠结局。

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