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首页> 外文期刊>Regulatory peptides. >Postnatal profile of plasma leptin concentrations in male and female rats: relation with the maturation of the pituitary-gonadal axis.
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Postnatal profile of plasma leptin concentrations in male and female rats: relation with the maturation of the pituitary-gonadal axis.

机译：雄性和雌性大鼠血浆瘦素浓度的出生后概况：与垂体-性腺轴成熟的关系。

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Leptin, the ob gene product, has been implicated in the initiation of puberty in mice and humans. However, it is not yet clear whether leptin also plays a pivotal role in promoting sexual maturation in rats. Based on the assumption that circulating leptin levels would increase during the peripubertal period if this hormone triggers puberty, we examined the developmental profile of plasma leptin from neonatal (day 1) through adult (day 85) age in both male and female rats and simultaneously monitored several important indices of pituitary-gonadal function. A significant elevation of plasma leptin during the peripubertal period was not observed in either male or female rats. Although this finding may not support leptin as a humoral factor triggering puberty, we observed a rise in leptin in both sexes from the second postnatal week, which clearly preceded the first significant elevations of luteinizing hormone and gonadal steroids. Therefore, it is still possible that leptin may play a role in promoting sexual maturation in rats of both sexes already from an early postnatal period. It seems that the role for leptin in sexual development is permissive, but not decisive, in rats.
机译：ob基因产物瘦蛋白Leptin与小鼠和人类的青春期有关。然而，尚不清楚瘦素是否在促进大鼠性成熟中也起关键作用。基于这样的假设：如果这种激素触发青春期，循环瘦素水平会在青春期前后增加，我们检查了雌性大鼠从新生（第1天）到成年（第85天）血浆瘦素的发育情况，并同时进行了监测垂体性腺功能的几个重要指标。在雄性或雌性大鼠中，未观察到青春期前后血浆瘦素的显着升高。尽管这一发现可能不支持瘦素作为引发青春期的体液因子，但我们从出生后第二周开始观察到男女瘦素的升高，这显然是在促黄体生成激素和性腺甾体的首次显着升高之前。因此，从出生后早期开始，瘦素仍可能在促进两性大鼠的性成熟中起作用。瘦素在性发育中的作用似乎在大鼠中是允许的，但不是决定性的。

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