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首页> 外文期刊>Biological Theory: integrating development, evolution & cognition >Mechano-sensing in Embryonic Biochemical and Morphologic Patterning: Evolutionary Perspectives in the Emergence of Primary Organisms
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Mechano-sensing in Embryonic Biochemical and Morphologic Patterning: Evolutionary Perspectives in the Emergence of Primary Organisms

机译：胚胎生化和形态模式中的机械感测：初级生物出现的进化观点。

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Embryogenesis involves biochemical patterning as well as mechanical morphogenetic movements, both regulated by the expression of the regulatory genes of development. The reciprocal interplay of morphogenetic movements with developmental gene expression is becoming an increasingly intense subject of investigation. The molecular processes through which differentiation patterning closely regulates the development of morphogenetic movements are today becoming well understood. Conversely, experimental evidence recently revealed the involvement of mechanical cues due to morphogenetic movements in activating mechano-transduction pathways that control both the differentiation and the active morphogenesis of fundamental events in embryonic tissue development. Here I will first focus on the central role the shape of biological structures of the molecular and mesoscopic cell scales plays in mechano-transduction. Then, after a short description of the genetic regulation of the Drosophila embryo mesoderm invagination at gastrulation—one of the best-understood morphogenetic movement of embryogenesis—I will detail the processes of differentiation and of active morphogenesis of Drosophila embryo gastrulation, which require mechano-transduction. Finally, I willexplore the putative consequences in evolution of these mechano-transduction events. I speculate that the first ancient multicellular organisms might have emerged from primary morphological and differentiation patterns induced by primitive mechano-sensation effects allowed by mechano-transduction in response to their physical environment, such as touchby gravity or water flows, which might have acted as primitive motor-sensorial systems, thus conditioning the emergence of our primary animal ancestors.
机译：胚胎发生涉及生化模式以及机械形态发生运动，两者均受发育调控基因的表达调控。形态发生运动与发育基因表达的相互影响正日益成为研究的热点。如今，人们已逐渐了解分化模式通过其紧密调节形态发生运动发展的分子过程。相反，最近的实验证据表明，由于形态发生运动而引起的机械线索参与了激活机械转导途径，从而控制了胚胎组织发育中基本事件的分化和主动形态发生。在这里，我将首先关注分子和介观细胞尺度的生物学结构的形状在机械转导中的重要作用。然后，在简要介绍果蝇胚胎中胚层中胚层侵袭的遗传调控（胚发生的最容易理解的形态发生运动之一）之后，我将详细介绍果蝇胚胎胚发生的分化和活跃形态发生的过程，这需要机械力。转导。最后，我将探讨这些机械转导事件演变过程中的假定结果。我推测最早的古代多细胞生物可能是由原始机械感作用诱导的主要形态和分化模式而产生的，这些原始机械感作用是由机械转导响应其物理环境而产生的，例如通过重力或水流引起的，这些作用可能是原始的运动感应系统，从而调节了我们主要动物祖先的出现。

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