...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Cell cycle >A coordinated codon-dependent regulation of translation by Elongator
【24h】

A coordinated codon-dependent regulation of translation by Elongator

机译：Elongator的依赖于密码子的协调翻译调控

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

More than a decade ago, the purification of the form of the RNA polymerase II (PolII) engaged in elongation led to the discovery of an associated, multi-subunit (Elp1-6) complex named "Elongator" by the Svejstrup lab. Although further evidence supported the original notion that Elongator is involved in transcription, Elongator lacked some of the expected features for a regulator of the elongating PolII. The discovery by the Bystr?m lab, based on genetic dissection, that Elongator is pivotal for tRNA modifications, and that all the reported phenotypes of Elongator mutants are suppressed by the overexpression of two tRNAs added to the confusion. The increasing range of both potential substrates and biological processes regulated by Elongator in higher eukaryotes indicates that the major challenge of the field is to determine the biologically relevant function of Elongator. Our recent proteome-wide study in fission yeast supports a coordinated codon-dependent regulation of translation by Elongator. Here we provide additional analyses extending this hypothesis to budding yeast and worm.
机译：十多年前，参与延伸的RNA聚合酶II（PolII）形式的纯化导致Svejstrup实验室发现了一种名为“ Elongator”的相关多亚基（Elp1-6）复合物。尽管进一步的证据支持了Elongator参与转录的原始概念，但Elongator缺乏用于延长PolII调控子的某些预期功能。 Bystr？m实验室基于遗传解剖发现，Elongator对于tRNA修饰至关重要，并且所报道的Elongator突变体的所有表型都被添加到混乱中的两个tRNA的过表达所抑制。在高级真核生物中，潜在的底物和受Elongator调控的生物过程的范围不断扩大，这表明该领域的主要挑战是确定Elongator的生物学相关功能。我们最近在裂变酵母中进行的全蛋白质组研究支持Elongator对翻译进行协调的密码子依赖性调节。在这里，我们提供了其他分析，将这一假设扩展到了发芽的酵母和蠕虫。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号