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首页> 外文期刊>Cell cycle >Mammalian neo-oogenesis and expression of meiosis-specific protein SCP3 in adult human and monkey ovaries.
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Mammalian neo-oogenesis and expression of meiosis-specific protein SCP3 in adult human and monkey ovaries.

机译：哺乳动物新卵发生和成年人类和猴卵巢中减数分裂特异性蛋白SCP3的表达。

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The concept of neo-oogenesis and follicular renewal during adulthood in mammalian females, including humans, is a novel concept with major significance for ovarian physiology and mammalian reproductive biology. Previous observations from our laboratory demonstrated that mesenchymal cells in the tunica albuginea are bipotent progenitors for both granulosa and germ cells in adult human ovaries. In the present studies, we demonstrate that the antibodies against meiotic entry synaptonemal complex protein 3 (SCP3)--a marker or meiosis, showed reactivity with segments of tunica albuginea and ovarian surface epithelium, and in oocytes of some primordial follicles in functional human and monkey ovaries. These observations suggest that SCP3 is expressed in adult human and monkey ovaries. Preparation for meiotic activity may have already occurred at the level of tunica albuginea stem cells, and meiotic prophase activity may continue and terminate in oocytes of newly formed primordial follicles.
机译：包括人类在内的哺乳动物女性在成年期的新卵子发生和卵泡更新的概念是一个新颖的概念，对卵巢生理学和哺乳动物生殖生物学具有重要意义。我们实验室以前的观察结果表明，白膜的间质细胞是成年卵巢中颗粒和生殖细胞的双能祖细胞。在本研究中，我们证明抗减数分裂进入突触复合蛋白3（SCP3）的抗体-一种标记物或减数分裂，与白膜膜和卵巢表面上皮的片段以及功能性人类和人类某些原始卵泡的卵母细胞中显示出反应性。猴子卵巢。这些观察结果表明SCP3在成年人类和猴子卵巢中表达。减数分裂活性的准备可能已经在白膜干细胞水平上进行了，减数分裂的前期活性可能会继续并终止于新形成的原始卵泡的卵母细胞中。

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