...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Cell cycle >The tumorigenicity of diploid and aneuploid human pluripotent stem cells.
【24h】

The tumorigenicity of diploid and aneuploid human pluripotent stem cells.

机译：二倍体和非整倍体人多能干细胞的致瘤性。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Human embryonic stem cells (HESCs) and induced pluripotent stem cells (HiPSCs) offer an immense potential as a source of cells for regenerative medicine. However, the ability of undifferentiated HESCs and HiPSCs to produce tumors in vivo presents a major obstacle for the translation of this potential into clinical reality. Therefore, characterizing the nature of HESC- and HiPSC-derived tumors, especially their malignant potential, is extremely important in order to evaluate the risk involved in their clinical use. Here we review recent observations on the tumorigenicity of human pluripotent stem cells. We argue that diploid, early passage, HESCs produce benign teratomas without undergoing genetic modifications. Conversely, HESCs that acquired genetic or epigenetic changes upon adaptation to in vitro culture can produce malignant teratocarcinomas. We discuss the molecular mechanisms of HESC tumorigenicity and suggest approaches to prevent tumor formation from these cells. We also discuss the differences in the tumorigenicity between mouse embryonic stem cells (MESCs) and HESCs, and suggest methodologies that may help to identify cellular markers for culture adapted HESCs.
机译：人类胚胎干细胞（HESC）和诱导多能干细胞（HiPSC）作为再生医学的细胞来源具有巨大的潜力。但是，未分化的HESC和HiPSC在体内产生肿瘤的能力为将这种潜力转化为临床现实提供了主要障碍。因此，表征HESC和HiPSC衍生肿瘤的性质，特别是其恶性潜能，对于评估其临床使用风险非常重要。在这里，我们审查有关人类多能干细胞的致瘤性的最新观察。我们认为，二倍体，早期传代，HESCs产生良性畸胎瘤而无需进行基因改造。相反，在适应体外培养后获得遗传或表观遗传学改变的HESC可以产生恶性畸胎癌。我们讨论了HESC致瘤性的分子机制，并提出了防止这些细胞形成肿瘤的方法。我们还讨论了小鼠胚胎干细胞（MESC）和HESC之间在致瘤性方面的差异，并提出了可能有助于鉴定培养适应性HESC的细胞标志物的方法。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号