The report by Hackenback et al. addresses the interface between cell cycle control and one of the key external requirements for normal cell function-oxygen. They have explored the effect of activating Hypoxia-Inducible Factor (HIF), a specific transcriptional response to low oxygen, on cell cycle progression. Using an elegant system to express constitutively active versions of HIF-1 a and HIF-2alpha under conditions of normal oxygenation, they establish that either of these is sufficient to arrest NIH3T3 cells in G_1.
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