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首页> 外文期刊>Cell cycle >Gene expression profile at the G1/S transition of liver regeneration after partial hepatectomy in mice.
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Gene expression profile at the G1/S transition of liver regeneration after partial hepatectomy in mice.

机译：小鼠部分肝切除术后肝再生的G1 / S过渡期的基因表达谱。

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摘要

Liver is a quiescent organ with >90% of the cells present in the G(0) stage of the cell cycle. However, adult hepatocytes have enormous ability to proliferate in response to liver injury. After 70% liver resection hepatocytes enter the cell cycle in a highly synchronized manner and undergo 1 to 2 rounds of cell division to restore the lost organ mass, thus, representing one of the most reliable model systems to study cell cycle progression in vivo. Using high density oligonucleotide micro-array we analyzed the expression patterns of genes at the G(1)/S transition of liver regeneration in comparison to quiescent livers. The G(1)/S boundary was identified by in vivo BrdU pulse labeling and we observed 199 genes/ESTs which were either up/down regulated at this time point. These differentially regulated genes have a wide range of functions including transcriptional regulation, signal transduction, cell cycle regulation, chromatin reorganization, protein targeting, metabolism, transport, surface receptors, circadian rhythms, xenobiotic metabolism, inflammation and acute phase response. The functions of most of the genes identified in this screen are not known in the process of liver regeneration and cell cycle control at G(1)/S transition.
机译：肝是一个静止的器官，在细胞周期的G（0）阶段存在> 90％的细胞。然而，成年肝细胞具有响应肝脏损伤而增殖的巨大能力。肝切除70％后，肝细胞以高度同步的方式进入细胞周期并经历1至2轮细胞分裂以恢复丢失的器官质量，因此，代表了研究体内细胞周期进程的最可靠的模型系统之一。使用高密度寡核苷酸微阵列，我们分析了与静止肝脏相比，肝脏再生的G（1）/ S过渡时期的基因表达模式。 G（1）/ S边界是通过体内BrdU脉冲标记识别的，我们观察到199个基因/ EST在这个时间点上/下调。这些差异调节的基因具有广泛的功能，包括转录调节，信号转导，细胞周期调节，染色质重组，蛋白质靶向，代谢，转运，表面受体，昼夜节律，异生物代谢，炎症和急性期反应。在此屏幕中鉴定的大多数基因的功能在肝脏再生和G（1）/ S过渡的细胞周期控制过程中尚不清楚。

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