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Eph receptor and mTOR pathway crosstalk: Implications for cancer.

机译:Eph受体和mTOR通路的串扰:对癌症的影响。

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摘要

Eph receptors constitute the largest family of receptor tyrosine kinases in the mammalian genome containing at least fourteen members. Unlike most other receptor kinases that bind secreted proteins, Eph receptors bind membrane-anchored ligands called ephrins. Eph receptors are divided into two classes based on their sequence homology and ligand binding properties. Those that bind the glycosylphosphati-dylinositol (GPI) linked ephrin-A ligands are called the EphA group while those that bind transmembrane ephrin-B ligands are called the EphB group.
机译:Eph受体构成了至少包含14个成员的哺乳动物基因组中最大的受体酪氨酸激酶家族。与大多数其他结合分泌蛋白的受体激酶不同,Eph受体结合称为ephrin的膜锚定配体。 Eph受体根据其序列同源性和配体结合特性分为两类。结合糖基磷脂酰肌醇(GPI)连接的ephrin-A配体的那些被称为EphA基团,而结合跨膜ephrin-B配体的那些被称为EphB基团。

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