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首页> 外文期刊>Cell cycle >Eph receptors tangled up in two: Independent control of cell positioning and proliferation.
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Eph receptors tangled up in two: Independent control of cell positioning and proliferation.

机译：Eph受体缠结成两部分：细胞位置和增殖的独立控制。

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摘要

Eph receptors constitute the largest family of tyrosine kinase receptors. They interact at direct cell-cell contacts with their membrane-bound ephrin ligands, which also are capable of signaling. Ephrins and Ephs regulate many diverse processes during embryonic development, in most cases by affecting the cytoskeleton.In spite of the notoriety of tyrosine kinase receptors as regulators of cell proliferation, it was initially thought that Eph receptors represented an exception and that they were unable to affect the cell cycle. More recently, Ephs and ephrins have been found to be expressed in several adult stem cell niches, such as the brain, skin and intestine, and to regulate the proliferation of stem/progenitor cells. Moreover, Eph receptors can act both as tumor promoters and tumor suppressors, depending on the cellular context.
机译：Eph受体构成最大的酪氨酸激酶受体家族。它们在直接的细胞接触中与膜结合的ephrin配体相互作用，后者也能够发出信号。 Ephrins和Ephs在胚胎发育过程中调节许多不同的过程，在大多数情况下会影响细胞骨架。尽管酪氨酸激酶受体作为细胞增殖的调节因子而臭名昭著，但最初人们认为Eph受体是一个例外，并且他们不能影响细胞周期。最近，人们发现Ephs和ephrins在几个成年的干细胞壁ni中表达，例如大脑，皮肤和肠道，并调节干细胞/祖细胞的增殖。此外，Eph受体可以根据细胞情况同时充当肿瘤启动子和抑癌剂。

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