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首页> 外文期刊>Regulatory Toxicology and Pharmacology: RTP >Asphalt fume dermal carcinogenicity potential: II. Initiation-promotion assay of Type III built-up roofing asphalt.
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Asphalt fume dermal carcinogenicity potential: II. Initiation-promotion assay of Type III built-up roofing asphalt.

机译：沥青烟的皮肤致癌性：II。 III型组合式屋面沥青的引发-促进试验。

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Clark et al. (accepted for publication) reported that a sample of field-matched fume condensate from a Type III built-up roofing asphalt (BURA) resulted in a carcinogenic response in a mouse skin bioassay, with relatively few tumor-bearing animals, long tumor latency and chronic skin irritation. This mouse skin initiation/promotion study was conducted to assess possible mechanisms, i.e., genotoxic initiation vs. tumor promotion subsequent to repeated skin injury and repair. The same Type III BURA fume condensate sample was evaluated in groups of 30 male Crl:CD1(R) mice by skin application twice per week (total dose of 50 mg/week) for 2 weeks during the initiation phase and for 26 weeks during the promotion phase. Positive control substances were 7,12-dimethylbenz(a)anthracene (DMBA, 50 mug applied once) as an initiator and 12-O-tetradecanoyl-13-acetate (TPA, 5 mug, applied twice weekly) during the promotion phase. During the 6 months of study with the asphalt fume condensate, eight skin masses were observed when tested for initiation, five of which were confirmed microscopically to be benign squamous cell papillomas. Only two papillomas were observed when tested for promotion. There was no apparent relationship between skin irritation and tumor development in this study. These results are more indicative of genotoxicity rather than a non-genotoxic mode of action.
机译：克拉克等。 （已接受发表）报告说，来自III型组合式屋面沥青（BURA）的现场匹配烟气冷凝物样品在小鼠皮肤生物测定中导致了致癌反应，相对而言，荷瘤动物相对较少，肿瘤潜伏期长，慢性皮肤刺激。进行该小鼠皮肤启动/促进研究以评估可能的机制，即在反复皮肤损伤和修复后的遗传毒性启动与肿瘤促进。通过在初始阶段每周两次皮肤应用（总剂量为50 mg /周），在起始阶段每周2次，在启动期间26周，在30只雄性Crl：CD1（R）小鼠的组中评估相同的III型BURA烟雾冷凝物样品。推广阶段。在促进阶段，阳性对照物质为7,12-二甲基苯并（a）蒽（DMBA，50杯，一次）和12-O-十四烷酰基-13-乙酸盐（TPA，5杯，每周两次）。在使用沥青烟气冷凝液进行的6个月研究中，测试初始皮肤时观察到8个皮肤肿块，其中5个在显微镜下被确认为良性鳞状细胞乳头状瘤。当测试促进时，仅观察到两个乳头状瘤。在这项研究中，皮肤刺激与肿瘤的发展之间没有明显的关系。这些结果更能说明遗传毒性而不是非遗传毒性作用方式。

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