• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Regulatory Toxicology and Pharmacology: RTP >Toxicological evaluation of Gumiganghwaltang aqueous extract in Crl: CD (SD) rats: 13weeks oral gavage studies
【24h】

Toxicological evaluation of Gumiganghwaltang aqueous extract in Crl: CD (SD) rats: 13weeks oral gavage studies

机译：Gumiganghwaltang水提取物在Crl：CD（SD）大鼠中的毒理学评估：13周口腔管饲研究

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Gumiganghwaltang is a traditional oriental herbal medicine that has been commonly used to treat colds and inflammatory diseases. Aqueous extract of Gumiganghwaltang (GMGHT) was administrated daily by oral gavage to male and female rats for 13. weeks. A dose of 2000. mg/kg/day was selected as a maximum, and doses of 1000 and 500. mg/kg/day were determined as medium and low doses, respectively. No treatment-related clinical signs or mortality were observed in the treatment group. We observed no clear treatment-related effects with regard to body weight, food consumption, ophthalmology, hematology, or urinalysis data. The serum biochemistry values for sodium and chloride in the treated male and female groups (1000. mg/kg/day) were lower than in those treated with the vehicle control. However, these changes lacked dose dependence, and no abnormalities were found in corresponding pathological findings. Our results indicated that the no-observed-adverse-effect-level (NOAEL) for GMGHT was determined to be a dietary dose of over 2000. mg/kg/day for both sexes under the present experimental conditions.
机译：Gumiganghwaltang是一种传统的东方草药，通常用于治疗感冒和炎性疾病。每天通过灌胃法对雄性和雌性大鼠施用古米岗华汤水提取物（GMGHT），持续13周。最高剂量为2000. mg / kg /天，最高剂量和低剂量分别为1000和500. mg / kg /天。在治疗组中未观察到与治疗相关的临床体征或死亡率。我们没有观察到与体重，食物消耗，眼科，血液学或尿液分析数据有关的与治疗相关的明确影响。在处理过的男性和女性组中，钠和氯化物的血清生化值（1000. mg / kg /天）低于用媒介物对照处理的那些。然而，这些变化缺乏剂量依赖性，并且在相应的病理学发现中未发现异常。我们的结果表明，在目前的实验条件下，对于两性而言，GMGHT的未观察到的不良反应水平（NOAEL）被确定为超过2000. mg / kg /天的饮食剂量。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号