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首页> 外文期刊>Cell cycle >Linking oncogenes to invasion in thyroid cancer.
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Linking oncogenes to invasion in thyroid cancer.

机译：将癌基因与甲状腺癌的侵袭联系起来。

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摘要

Thyroid cancer prognosis, like that of many solid tumors, is predicted by the presence or absence of distant metastasis, gross local invasion, tumor size, patient age and tumor histology. Local invasion is a particularly vexing issue for patients with large papillary thyroid cancers, as grossly invasive tumors can be difficult to treat and are associated with an aggressive course. Moreover, it has been recognized increasingly that radioactive iodine therapy, the most frequently used systemic treatment for recurrent or residual thyroid cancer following initial surgery, is often ineffective when the residual cancer invades muscle or trachea. Aggressive completion surgery and external beam radiation therapies are associated with difficult side effects and are often not curative.
机译：像许多实体瘤一样，甲状腺癌的预后可通过是否存在远处转移，总体局部浸润，肿瘤大小，患者年龄和肿瘤组织学来预测。对于患有大乳头状甲状腺癌的患者来说，局部浸润是一个特别令人烦恼的问题，因为严重浸润性肿瘤可能难以治疗且与侵袭性病程相关。此外，人们日益认识到，放射性碘疗法是初始手术后复发或残留甲状腺癌的最常用的全身治疗方法，当残留癌侵袭肌肉或气管时通常无效。激进的完成手术和外部束放射疗法与困难的副作用有关，通常不能治愈。

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