A touching moment for Smc5/6: from ssDNA binding to repair.

Ohouo PY; Smolka MB

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A touching moment for Smc5/6: from ssDNA binding to repair.

机译：Smc5 / 6的感人时刻：从ssDNA结合到修复。

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Members of the structural maintenance of chromosome (SMC) family of proteins form specialized molecular machines that perform vital functions in chromosome biology. The characteristic ring-shaped structure of the SMC complexes, together with their ATPase activity, makes them uniquely suited to regulate the dynamic structure of chromosomes. SMC complexes are best known for their roles in chromosome condensation and sister chromatid cohesion, which are mediated by the Smc1/3 and Smc2/4 complexes, respectively. A third and less understood SMC complex involving the Smc5 and Smc6 proteins is intimately involved in DNA damage repair (reviewed in refs. 1 and 2). Like the other SMC complexes, the Smc5/6 complex is required for cell viability and is highly conserved among eukaryotes. The Smc5/6 complex contains six additional Non-SMC Elements (Nse1-6), including the Mms21 (Nse2) sumo-ligase. Genetic and biochemical studies of hypomorphic smc5, smc6 and mms21 alleles point to the direct involvement of the Smc5/6 complex in repair via homologous recombination (HR). Cells expressing the sumo ligase-deficient allele of Mms21, mms21-CH, were shown to accumulate X-shaped DNA structures at stalled replication forks.

机译：蛋白质染色体（SMC）家族的结构维护成员组成了专门的分子机器，这些机器在染色体生物学中起着至关重要的作用。 SMC复合物的特征性环状结构及其ATPase活性使其特别适合调节染色体的动态结构。 SMC复合物因其在染色体浓缩和姐妹染色单体内聚中的作用而广为人知，这分别由Smc1 / 3和Smc2 / 4复合物介导。涉及Smc5和Smc6蛋白的第三个鲜为人知的SMC复合体与DNA损伤修复密切相关（参见参考文献1和2）。像其他SMC复合物一样，Smc5 / 6复合物是细胞活力所必需的，并且在真核生物中高度保守。 Smc5 / 6复合体包含六个附加的非SMC元素（Nse1-6），包括Mms21（Nse2）相扑连接酶。亚型smc5，smc6和mms21等位基因的遗传和生化研究表明，Smc5 / 6复合体通过同源重组（HR）直接参与修复。表示表达Mms21的相扑连接酶缺陷等位基因的细胞mms21-CH在停滞的复制叉处积聚了X形DNA结构。

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《Cell cycle》 |2011年第8期|共2页
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Ohouo PY; Smolka MB;
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中图分类细胞生物学;
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1. A touching moment for Smc5/6: from ssDNA binding to repair. [J] . Ohouo PY, Smolka MB Cell cycle . 2011,第8期

机译：Smc5 / 6的感人时刻：从ssDNA结合到修复。
2. Allosteric interactions between the nucleotide-binding sites and the ssDNA-binding site in the PriA helicase - ssDNA complex. 3 [J] . Lucius AL, Jezewska MJ, Bujalowski W Biochemistry . 2006,第23期

机译：PriA解旋酶-ssDNA复合体中核苷酸结合位点与ssDNA结合位点之间的变构相互作用。 3
3. The Borrelia burgdorferi telomere resolvase, ResT, anneals ssDNA complexed with its cognate ssDNA-binding protein [J] . Huang Shu Hui, Kobryn Kerri Nucleic Acids Research . 2016,第11期

机译：伯氏疏螺旋体端粒解离酶ResT退火与其同源ssDNA结合蛋白复合的ssDNA
4. Visio-tactile binding through double-touching by a robot with an anthropomorphic tactile sensor [C] . Yoshikawa, Y., Yoshimura, . 2005

机译：带有拟人触觉传感器的机器人通过双触来进行视触结合
5. The mechanisms of dTTP hydrolysis and ssDNA binding by the T7 DNA helicase-primase and the role of magnesium(2+) in these processes. [D] . Picha, Kristen Moore. 2000

机译：dTTP水解和ssDNA结合的T7 DNA解旋酶-引发酶的机制以及镁（2+）在这些过程中的作用。
6. Acidic C-terminal tail of the ssDNA-binding protein of bacteriophage T7 and ssDNA compete for the same binding surface [O] . Boriana Marintcheva, Assen Marintchev, Gerhard Wagner, 2008

机译：噬菌体T7的ssDNA结合蛋白的酸性C末端尾巴与ssDNA竞争同一结合表面
7. TheBorrelia burgdorferitelomere resolvase, ResT, anneals ssDNA complexed with its cognate ssDNA-binding protein [O] . Shu Hui Huang, Kerri Kobryn 2016

机译：TheBorrelia BurgdorferitEtelomere soldvase，休息，退火SSDNA与其同源SSDNA结合蛋白复合

A touching moment for Smc5/6: from ssDNA binding to repair.

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