The 'Sharp' blade against HIF-mediated metastasis

AmelioI.; MelinoG.

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The 'Sharp' blade against HIF-mediated metastasis

机译：对抗HIF介导的转移的“锋利”刀片

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Hypoxia-inducible factors (HIFs) control cellular adaptation to oxygen deprivation. Cancer cells engage HIFs to sustain their growth in adverse conditions, thus promoting a cellular reprograming that includes metabolism, proliferation, survival and mobility. HIFs overexpression in human cancer biopsies correlates with high metastasis and mortality. A recent report has elucidated a novel mechanism for HIFs regulation in triple-negative breast cancer. Specifically, the basic helix-loop-helix (bHLH), Sharp-1, serves HIF1á to the proteasome and promotes its O2-indendpendet degradation, counteracting HIF-mediated metastasis. These findings shed light on how HIFs are manipulated during cancer pathogenesis.

机译：缺氧诱导因子（HIFs）控制细胞对缺氧的适应。癌细胞与HIF结合以在不利条件下维持其生长，从而促进细胞的重新编程，包括新陈代谢，增殖，存活和迁移。 HIFs在人类癌症活检组织中的过表达与高转移和高死亡率相关。最近的一份报告阐明了三阴性乳腺癌中HIF调控的新机制。具体来说，基本的螺旋-环-螺旋（bHLH）Sharp-1可以为蛋白酶体提供HIF1á，并促进其O2-齿根降解，从而抵消HIF介导的转移。这些发现揭示了在癌症发病过程中如何操纵HIF。

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《Cell cycle》 |2012年第24期|共6页
作者
AmelioI.; MelinoG.;
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正文语种 eng
中图分类细胞生物学;
关键词
Angiogenesis; Breast cancer; Cancer metabolism; HIF; Hypoxia; Metastasis; p63; Sharp1; VHL;

机译：血管生成;乳腺癌;癌症代谢;HIF;缺氧;转移;p63;Sharp1;VHL;

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专利

1. The "Sharp" blade against HIF-mediated metastasis [J] . AmelioI., MelinoG. Cell cycle . 2012,第24期

机译：对抗HIF介导的转移的“锋利”刀片
2. Comminution with blades without a cutting edge. Effects of blade sharpness on quality of model emulsions and their end products. [J] . Micklisch I, Schnaeckel W, Krickmeier J, Fleischwirtschaft . 2005,第1期

机译：切碎无刀刃的刀片。刀片锋利度对模型乳液及其最终产品质量的影响。
3. Blade grinder sharpens chip breaker blades [J] . The tube & pipe journal . 2003,第3期

机译：刀片磨床磨削断屑刀片
4. Optimizing Blade Gap With Various Sharpness for Plate Shearing [C] . Qiulin Yu, Mark Zeleney, Tyler Watkins, Iron and Steel Technology Conference . 2016

机译：优化刀片间隙，具有各种锐度的板剪切
5. “Sharpen Your Blade and Put Your Animal at Ease”: Islamic Ethics and Rituals of Killing Non-Human Animals [D] . Friedlander, Nuri. 2020

机译：“削尖你的刀片并放松地放血”：伊斯兰伦理和杀死非人类动物的仪式
6. The Sharp blade against HIF-mediated metastasis [O] . Ivano Amelio, Gerry Melino 2012

机译：对抗HIF介导的转移的锋利刀片
7. The "Sharp" blade against HIF-mediated metastasis [O] . Amelio, I, Melino, G 2012

机译：对抗HIF介导的转移的“锋利”刀片
8. A DYNAMIC MODEL INVESTIGATION OF THE EFFECT OF A.SHARP-EDGE VERTICAL GUST ON BLADE PERIODIC FLAPPING ANGLES AND BENDING MOMENTS OF A TWO-BLADE ROTOR [R] . John Locke McCarty, George W. Brooks, Domenic J. Maglieri 1959

机译：a.sHaRp-EDGE垂直燃烧对叶片周期性摆动角度和双叶片转子弯曲力矩影响的动态模型研究

The 'Sharp' blade against HIF-mediated metastasis

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