p53: The pivot between cell cycle arrest and senescence.

Santoro R; Blandino G

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p53: The pivot between cell cycle arrest and senescence.

机译：p53：细胞周期停滞与衰老之间的枢纽。

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Pura was previously described as a nucleic acid-binding factor with DNA unwinding properties.6 The recent finding described by Kaminski et al. has provided a brand new perspective on the biological functions of Pura, which is now emerging as a multi-functional factor in cellular and molecular biology. Undoubtedly, the demonstration of a physical association between Pura and TFIIH has provided a useful insight into the study of NER mechanism.' Another study has reported that an enhanced NER activity is linked to cisplatin resistance in non-small cell lung cancer.7 In this respect, Pura was able to confer cisplatin resistance to malignant cells as well,8 which further supports the finding that Pura is one of the key players in the NER pathway. However, these findings, taken together, indicate that the NER system may be considered a double-edged sword.

机译：Pura先前被描述为具有DNA解链特性的核酸结合因子。6Kaminski等人最近描述的发现。为Pura的生物学功能提供了崭新的视角，Pura现已成为细胞和分子生物学中的多功能因子。毫无疑问，Pura和TFIIH之间物理联系的证明为NER机制的研究提供了有用的见识。”另一项研究报道，在非小细胞肺癌中，NER活性增强与顺铂耐药性相关。7在这一方面，Pura还能对恶性细胞赋予顺铂耐药性，8进一步证明了Pura是一种NER途径中的关键参与者。但是，这些发现加在一起表明NER系统可能被视为一把双刃剑。

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《Cell cycle》 |2010年第21期|共2页
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Santoro R; Blandino G;
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正文语种 eng
中图分类细胞生物学;
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1. p53: The pivot between cell cycle arrest and senescence. [J] . Santoro R, Blandino G Cell cycle . 2010,第21期

机译：p53：细胞周期停滞与衰老之间的枢纽。
2. Conditional inactivation of PDCD2 induces p53 activation and cell cycle arrest Conditional inactivation of PDCD2 induces p53 activation and cell cycle arrest Conditional inactivation of PDCD2 induces p53 activation and cell cycle arrest [J] . Hatem E. Sabaawy, Wei Wang, Ruth Steward, Biology Open . 2014,第9期

机译：PDCD2的条件失活诱导p53活化和细胞周期阻滞PDCD2的条件失活诱导p53活化和细胞周期阻滞PDCD2的条件失活诱导p53活化和细胞周期阻滞
3. Levels of p53 in Epstein-Barr virus-infected cells determine cell fate: apoptosis, cell cycle arrest at the G1/S boundary without apoptosis, cell cycle arrest at the G2/M boundary without apoptosis, or unrestricted proliferation. [J] . Chen W, Huang S, Cooper NR Virology . 1998,第2期

机译：受爱泼斯坦-巴尔病毒感染的细胞中p53的水平决定了细胞的命运：细胞凋亡，细胞周期停滞在G1 / S边界而没有凋亡，细胞周期停滞在G2 / M边界而没有凋亡或增殖不受限制。
4. INCREASED LEVELS OF P21 BUT NOT P53 MAY BE ASSOCIATED WITH CELL CYCLE ARREST OF CANINE OSTEOSARCOMA CELLS IN RESPONSE TO 2-METHOXYESTRADIOL-2 (2ME2) TREATMENT [C] . Sharon Shor, Kevin Marley, Bernard Seguin, Annual conference of the Veterinary Cancer Society . 2008

机译：P21的水平增加，但不是P53可能与犬骨肉瘤细胞的细胞周期停留有关，响应2-甲氧基雌激素-2（2ME2）处理
5. RS-41, A multi-targeted kinase inhibitor, induces cell cycle arrest and apoptosis in P53 mutant and wild type models of upper gastrointestinal cancers. [D] . Visal, Tanvi. 2017

机译：RS-41是一种多靶点激酶抑制剂，在上消化道癌的P53突变型和野生型模型中诱导细胞周期停滞和凋亡。
6. Cell-cycle arrest and senescence in TP53-wild type renal carcinoma by enhancer RNA-P53-bound enhancer regions 2 (p53BER2) in a p53-dependent pathway [O] . Haibiao Xie, Kaifang Ma, Kenan Zhang, 2021

机译：通过增强子RNA-P53-结合的增强剂（P53BER2）在P53依赖性途径中的细胞周期停滞和TP53-野生型肾癌中的衰老
7. Levels of p53 in Epstein–Barr Virus-Infected Cells Determine Cell Fate: Apoptosis, Cell Cycle Arrest at the G1/S Boundary without Apoptosis, Cell Cycle Arrest at the G2/M Boundary without Apoptosis, or Unrestricted Proliferation [O] . Chen Weiping, Huang Shuang, Cooper Neil R. 1998

机译：爱泼斯坦-巴尔病毒感染的细胞中p53的水平决定了细胞的命运：细胞凋亡，在没有细胞凋亡的G1 / S边界处的细胞周期停滞，在没有细胞凋亡的G2 / M边界处的细胞周期停滞或增殖不受限制

p53: The pivot between cell cycle arrest and senescence.

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