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首页> 外文期刊>Cell cycle >PTK7: a cell polarity receptor with multiple facets.
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PTK7: a cell polarity receptor with multiple facets.

机译：PTK7：具有多个小平面的细胞极性受体。

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摘要

PTK7 is a tyrosine kinase receptor implicated in planar cell polarity, a process with multiple implications at the cellular and organism levels. Loss of function of PTK7 leads to profound morphogenetic defects in the mouse, such as neural tube defects, misorientation of stereocilia in the inner ear, and impaired polarized cell movements. The planar cell polarity pathway is classically assigned to a non-canonical Wnt pathway, which does not rely on b-catenin transcriptional activity. We recently revealed that PTK7 is implicated in b-catenin-dependent developmental processes in mammalian and Xenopus systems. Based on data recently obtained by our group as well as others, we discuss how PTK7 could be involved in canonical and non-canonical Wnt pathways, and which implications are expected from these data in physiology and physiopathology.
机译：PTK7是一种酪氨酸激酶受体，与平面细胞极性有关，该过程在细胞和生物体水平上具有多种含义。 PTK7的功能丧失会导致小鼠发生严重的形态发生缺陷，例如神经管缺陷，内耳中的立体纤毛方向错误以及极化细胞运动受损。平面细胞极性途径经典地分配给非经典的Wnt途径，该途径不依赖b-catenin转录活性。我们最近发现，PTK7与哺乳动物和非洲爪蟾系统中b-catenin依赖的发育过程有关。基于我们小组以及其他人最近获得的数据，我们讨论了PTK7如何参与规范性和非规范性Wnt途径，以及这些数据在生理学和生理病理学中的预期含义。

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