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MiR-33 connects cholesterol to the cell cycle

机译:MiR-33将胆固醇连接到细胞周期

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Cell cycle progression and cell proliferation are tightly controlled processes that are critical for normal development and organo-genesis, and deregulation of these processes may result in cancer.The cholesterol synthesis pathway is known to affect cell proliferation and cell cycle progression. Cholesterol is an essential component of cell membranes and organelles, and its synthesis is thereby tightly regulated by the sterol regulatory element-binding protein (SREBP) family of transcription factors.3 Three SREBP family members are known in humans, and they coordinate the expression of fatty acid metabolism and cholesterol metabolism-related genes.
机译:细胞周期进程和细胞增殖是严格控制的过程,对于正常发育和有机发生至关重要,这些过程的失控可能导致癌症。胆固醇合成途径已知会影响细胞增殖和细胞周期进程。胆固醇是细胞膜和细胞器的重要组成部分,因此其合成受到转录因子固醇调节元件结合蛋白(SREBP)家族的严格控制。3人类已知有3个SREBP家族成员,它们可以协调胆固醇的表达。脂肪酸代谢和胆固醇代谢有关的基因。

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