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首页> 外文期刊>Radiotherapy and oncology: Journal of the European Society for Therapeutic Radiology and Oncology >Effects of tamoxifen on pulmonary fibrosis after cobalt-60 radiotherapy in breast cancer patients.
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Effects of tamoxifen on pulmonary fibrosis after cobalt-60 radiotherapy in breast cancer patients.

机译：三苯氧胺对乳腺癌患者钴60放射治疗后肺纤维化的影响。

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BACKGROUND AND PURPOSE: This study was performed to investigate whether the tamoxifen (TAM) induced the development of pulmonary fibrosis after post-mastectomy cobalt-60 (Co-60) irradiation of chest wall and regional lymphatics in patients with breast cancer along with patient age, menopausal status, body weight, observation time and adjuvant chemotherapy regimens.MATERIALS AND METHODS: In this prospective study, 74 patients treated with post-mastectomy adjuvant radiotherapy (RT) and TAM and 37 patients treated with RT were evaluated by axial computerized tomography (CT). CT was first performed before initiation of radiotherapy and TAM treatment. A total of 824 thorax CT sections were evaluated by a radiologist blindly. Comparison of pre-treatment and post-treatment CT sections was used to monitor the development of pulmonary fibrosis.RESULTS: Pulmonary fibrosis developed in 26 of 74 patients who were treated with RT and TAM combination. It was found in five of 37 women treated only with RT. The difference was statistically significant (P<0.01). The median time for the development of pulmonary fibrosis was 8 months in TAM-treated patients whereas it was 10 months in non-TAM-treated patients. Among 111 patients who participated in that study, 65 were in the post-menopausal state and 46 in pre-menopausal state. In the multivariate analysis, the independent prognostic factors were age (P=0.010) and menopausal status (P=0.019). Advanced age and post-menopausal status predisposed to pulmonary fibrosis. The time interval in the development of lung fibrosis and body weight did not significantly influence the results. The time interval which is one independent prognostic factor was found to be associated with lung fibrosis under only-RT group in multivariate analysis (P<0.01).CONCLUSION: TAM treatment during post-mastectomy RT in breast cancer patients significantly increases the risk of the development of lung fibrosis along with the patient age and menopausal status.
机译：背景与目的：这项研究旨在探讨乳腺癌患者乳腺癌患者乳房切除术后钴60（Co-60）照射胸壁和区域淋巴瘤后，他莫昔芬（TAM）是否诱发肺纤维化的发展。材料和方法：在这项前瞻性研究中，对74例接受了乳房切除术后辅助放疗（RT）和TAM的患者和37例接受了RT的患者进行了轴向计算机断层扫描（ CT）。首先在开始放疗和TAM治疗之前进行CT检查。放射科医生对824例胸部CT切片进行了盲目评估。结果：在接受RT和TAM联合治疗的74例患者中，有26例发生了肺纤维化。在仅接受RT治疗的37位女性中，有5位被发现。差异具有统计学意义（P <0.01）。 TAM治疗的患者发生肺纤维化的中位时间为8个月，而非TAM治疗的患者为10​​个月。在参与该研究的111位患者中，有65位处于绝经后状态，有46位处于绝经前状态。在多因素分析中，独立的预后因素是年龄（P = 0.010）和绝经状态（P = 0.019）。高龄和绝经后状态易导致肺纤维化。肺纤维化和体重发展的时间间隔对结果没有显着影响。在多因素分析中，仅RT-组发现时​​间间隔是一个独立的预后因素，与肺纤维化有关（P <0.01）。结论：乳腺癌患者在乳房切除术后RTA期间进行TAM治疗显着增加了乳腺癌的风险。肺纤维化的发展以及患者的年龄和更年期状态。

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