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首页> 外文期刊>Radiotherapy and oncology: Journal of the European Society for Therapeutic Radiology and Oncology >Acute radiation-induced toxicity of heavy ion radiotherapy delivered with intensity modulated pencil beam scanning in patients with base of skull tumors.
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Acute radiation-induced toxicity of heavy ion radiotherapy delivered with intensity modulated pencil beam scanning in patients with base of skull tumors.

机译：强度调制铅笔束扫描对颅底肿瘤患者的重离子放射治疗具有急性放射诱导的毒性。

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PURPOSE: The purpose of this paper is to evaluate acute radiation-induced toxicity of carbon ion therapy.MATERIAL AND METHODS: From December 1997 to November 2000, 37 patients with chordomas and low-grade chondrosarcomas of the skull base have been treated with carbon ions at the heavy ion synchrotron (SIS) at GSI, Darmstadt. Tumor-conformal application of carbon beams was realized by intensity-controlled raster scanning in combination with pulse-to-pulse energy variation. The treatment planning procedure included a biological plan optimization. We applied a cobalt-Gray equivalent dose of 60GyE. Acute toxicity was assessed according to the common toxicity criteria (CTC).RESULTS: Acute toxicity included skin reactions ( degrees I+ degrees II) in four patients, mucositis ( degrees I- degrees III) in eight patients, otitis and middle ear effusion in four, sinusitis in four, nausea/weight loss in one and edema of the temporal lobes in one patient. In two patients, preexisting neurological symptoms worsened. We did not observe acute morbidity > degrees III of normal tissues.CONCLUSION: Scanning beam delivery of heavy charged particles is safe and reliable. No unexpected acute dose limiting toxicity was observed. With regard to toxicity, a substantial improvement compared to passive beam shaping technology is achieved.
机译：目的：本文的目的是评估碳离子治疗的急性放射毒性。材料与方法：自1997年12月至2000年11月，已有37例颅底脊索瘤和低度软骨肉瘤患者接受了碳离子治疗。在达姆施塔特GSI的重离子同步加速器（SIS）上。碳束的肿瘤适形应用是通过强度控制的光栅扫描结合脉冲间能量变化实现的。治疗计划程序包括生物计划的优化。我们应用了60GyE的钴灰色等效剂量。结果：急性毒性包括四名患者的皮肤反应（I级至II级），八名患者的粘膜炎（I级至III级），四名中耳炎和中耳积液。 ，四分之一的鼻窦炎，一分的恶心/体重减轻和一副颞叶浮肿。在两名患者中，先前存在的神经系统症状恶化。我们未观察到正常组织的急性发病率> III度。结论：扫描束传输重带电粒子是安全可靠的。没有观察到意外的急性剂量限制性毒性。关于毒性，与无源光束整形技术相比，有了实质性的改进。

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