Reprogramming specific gene expression pathways in B-cell lymphomas.

Melnick A

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Reprogramming specific gene expression pathways in B-cell lymphomas.

机译：重新编程B细胞淋巴瘤中的特定基因表达途径。

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The BCL6 transcriptional repressor is normally expressed during the germinal center phase of B-cell differentiation. Germinal center B-cells typically undergo rapid proliferation in spite of accumulating DNA damage caused by class switch recombination and somatic hypermutation. BCL6 is required to license B-cells for the germinal center reaction and its down regulation appears to be important for cells to exit this stage and undergo further differentiation. BCL6 appears to mediate these biological effects by recruiting corepressor complexes to silence critical cell cycle checkpoint and differentiation related genes. Based on our data and recent publications, we propose that these gene pathways are regulated through distinct transcriptional mechanisms, which can be specifically targeted to reprogram B-cells preferentially for either growth suppression and apoptosis, or differentiation. As BCL6 plays a central role in the pathogenesis of diffuse large B-cell lymphoma, we predict that targeting BCL6 transcriptional repression complexes in malignant B-cells may constitute a novel form of transcription therapy for lymphomas and possibly other tumors.

机译：BCL6转录阻遏物通常在B细胞分化的生发中心阶段表达。尽管积累了由类别开关重组和体细胞超突变引起的DNA损伤，但生发中心B细胞通常会迅速增殖。需要BCL6许可B细胞进行生发中心反应，其下调似乎对于细胞退出此阶段并进行进一步分化非常重要。 BCL6似乎通过募集corepressor复合物来沉默关键的细胞周期检查点和分化相关基因来介导这些生物学效应。根据我们的数据和最新出版物，我们建议这些基因途径通过不同的转录机制进行调控，这些转录机制可以特异性地靶向重编程B细胞，优先用于生长抑制和凋亡或分化。由于BCL6在弥漫性大B细胞淋巴瘤的发病机理中起着核心作用，因此我们预测在恶性B细胞中靶向BCL6转录抑制复合物可能构成针对淋巴瘤和其他肿瘤的新型转录治疗形式。

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《Cell cycle》 |2005年第2期|共3页
作者
Melnick A;
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正文语种 eng
中图分类细胞生物学;
关键词
DNA-Binding Proteins; Gene Expression Regulation; Neoplastic; Lymphoma; B-Cell; DNA结合蛋白质类; 基因表达调控; 肿瘤; 淋巴瘤; B细胞; 阻遏蛋白质类; 信号传递;

机译：DNA-Binding Proteins;Gene Expression Regulation;Neoplastic;Lymphoma;B-Cell;DNA结合蛋白质类;基因表达调控;肿瘤;淋巴瘤;B细胞;阻遏蛋白质类;信号传递;

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专利

1. Reprogramming specific gene expression pathways in B-cell lymphomas. [J] . Melnick A Cell cycle . 2005,第2期

机译：重新编程B细胞淋巴瘤中的特定基因表达途径。
2. Variable expression of Epstein-Barr virus-induced gene 3 during normal B-cell differentiation and among B-cell lymphomas. [J] . Larousserie F, Bardel E, Coulomb Lhermine A, Journal of Pathology: Journal of the Pathological Society of Great Britain and Ireland . 2006,第3期

机译：在正常B细胞分化过程中以及B细胞淋巴瘤之间，爱泼斯坦巴尔病毒诱导的基因3的可变表达。
3. Differentiation stage-specific expression of microRNAs in B lymphocytes and diffuse large B-cell lymphomas. [J] . Malumbres R, Sarosiek KA, Cubedo E, Blood: The Journal of the American Society of Hematology . 2009,第16期

机译：microRNA在B淋巴细胞和弥漫性大B细胞淋巴瘤中的分化阶段特异性表达。
4. Classification and Survival Prediction in Diffuse Large B-Cell Lymphoma by Gene Expression Profiling [C] . Pierangela Bruno, Francesco Calimeri, Aldo Marzullo International Conference on Machine Learning, Optimization, and Data Science . 2019

机译：基因表达分析弥漫性大B细胞淋巴瘤的分类和生存预测
5. Identification of oncogenes in human B-cell and murine T-cell lymphomas. [D] . Kim, Rachel. 2002

机译：人B细胞和鼠T细胞淋巴瘤中致癌基因的鉴定。
6. Novel promoter upstream of the human c-myc gene and regulation of c-myc expression in B-cell lymphomas. [O] . D L Bentley, M Groudine 1986

机译：人c-myc基因上游的新型启动子和B细胞淋巴瘤中c-myc表达的调节。
7. Site-specific expression of polycomb-group genes encoding the HPC-HPH/PRC1 complex in clinically defined primary nodal and cutaneous large B-cell lymphomas. [O] . Raaphorst, F.M., Vermeer, M, Fieret, E, 2004

机译：在临床定义的原发性淋巴结和皮肤大B细胞淋巴瘤中，编码HPC-HPH / PRC1复合体的多梳基团基因的位点特异性表达。

Reprogramming specific gene expression pathways in B-cell lymphomas.

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