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首页> 外文期刊>Radiotherapy and oncology: Journal of the European Society for Therapeutic Radiology and Oncology >Short term toxicity profile for 32 sinonasal cancer patients treated with IMRT. Can we avoid dry eye syndrome?
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Short term toxicity profile for 32 sinonasal cancer patients treated with IMRT. Can we avoid dry eye syndrome?

机译:IMRT治疗的32例鼻鼻癌患者的短期毒性概况。我们可以避免干眼症吗?

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摘要

Intensity modulated radiation therapy (IMRT) was given for 32 patients with M0 sinonasal cancer, with a median follow-up of 15 months. Acute toxicity was mucositis grades 1-2 in 28 patients and grade 3 in four patients. No corneal injury was observed, except in one patient where it was present before the start of IMRT. Conjunctivitis and dry eye symptoms were mild (no grade 3-4 toxicity) and no evolution to dry eye syndrome was observed. We conclude that high dose conformality of IMRT results in mild acute toxicity and that IMRT allows avoiding dry eye syndrome by its ability to create concave dose distributions which avoid the main lacrimal glands. Follow-up it too short to evaluate local control, optic nerve or retinal toxicity.
机译:对32例M0鼻窦癌患者进行了调强放射治疗(IMRT),平均随访15个月。急性毒性是28例患者的1-2级粘膜炎和4例患者的3级。没有观察到角膜损伤,只有一名患者在IMRT开始前就已经存在。结膜炎和干眼症状较轻(无3-4级毒性),未观察到发展为干眼综合征。我们得出的结论是,IMRT的高剂量适形性会导致轻度的急性毒性,并且IMRT通过产生避开主要泪腺的凹入剂量分布的能力来避免干眼症。随访时间太短,无法评估局部控制,视神经或视网膜毒性。

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