...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Radiotherapy and oncology: Journal of the European Society for Therapeutic Radiology and Oncology >Neck node metastasis after successful brachytherapy for early stage tongue carcinoma.
【24h】

Neck node metastasis after successful brachytherapy for early stage tongue carcinoma.

机译：近距离放疗成功治疗早期舌癌后颈部淋巴结转移。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

BACKGROUND AND PURPOSE: The accuracy of factors for predicting lymph node metastasis in patients with early-stage (stage I and II) mobile tongue carcinoma and prognostic factors associated with the clinical and pathological findings of lymph node metastasis were examined.MATERIAL AND METHODS: Between 1971 and 1998, 616 patients with early stage mobile tongue carcinoma were treated by brachytherapy with or without external irradiation. Neck lymph node metastasis occurred in a total of 237 cases, and 191 of them were not associated with primary failure. Neck dissection was performed in 169 of these 191 cases, and 16 cases were treated by radiotherapy. A pathological analysis was possible in 159 of the 169 neck dissection cases.RESULTS: There were 88 tongue cancer recurrences, and the incidence of neck metastasis was 38% (191/528) in the cases of primary controlled early tongue carcinoma, and 25% (38/151) and 41% (153/377), in stage-I and -II carcinoma, respectively. Neck metastasis was diagnosed within 12 months in 80% of cases, and within 24 months in 95%. Macroscopic appearance, tumor thickness and tumor length were identified as significant risk factors by a univariate analysis, but macroscopic appearance was the only significant risk factor identified by a multivariate analysis (P<0.001). The incidence of cervical lymph node metastasis was 62% among the invasive/ulcerative type tongue carcinomas, and was lower among the superficial type and exophyticodular type (20 and 35%, respectively). Regional and/or distant failure occurred in 75 of the 169 neck dissection cases (44%). The incidence of regional/distant failure was extremely high (49/68=72%) in the extra-nodal invasion group, and extra-nodal invasion was found even in small metastatic node less than 1 cm in length (20%).CONCLUSIONS: The macroscopic appearance of the primary tongue carcinoma has a major impact on the incidence of lymph node metastasis in patients with early tongue cancer, and extra-nodal invasion was the dominant risk factor for regional and distant failure. Treatment policy for clinically negative neck metastasis in early tongue cancer patients should be determined after considering the possibility of neck metastases and the morbidity associated with elective neck dissection.
机译：背景与目的：探讨了早期（I和II期）活动性舌癌患者预测淋巴结转移的因素的准确性以及与淋巴结转移的临床和病理结果相关的预后因素。 1971年和1998年，对616例早期活动性舌癌患者进行了近距离放射治疗，有无外照射。共有237例发生颈部淋巴结转移，其中191例与原发性衰竭无关。在这191例病例中，有169例进行了颈部解剖，其中16例接受了放射治疗。结果：169例颈淋巴结清扫术中有159例进行了病理分析。结果：原发性早期舌癌在88例舌癌复发中，颈部转移发生率为38％（191/528），25％分别在I期和-II期癌中（38/151）和41％（153/377）。 80％的病例在12个月内诊断出颈部转移，95％的病例在24个月内诊断出颈部转移。通过单变量分析将宏观外观，肿瘤厚度和肿瘤长度确定为重要的危险因素，但通过多变量分析确定宏观外观是唯一的重要危险因素（P <0.001）。在浸润性/溃疡性舌癌中，颈部淋巴结转移的发生率是62％，而在浅表性和外生性/结节性癌中则较低（分别为20％和35％）。 169例颈清扫病例中有75例发生区域性和/或远距离衰竭（44％）。在结外侵袭组中，区域性/远距离衰竭的发生率极高（49/68 = 72％），即使在长度小于1 cm（20％）的小转移结中也发现了结外侵袭。 ：原发性舌癌的宏观外观对早期舌癌患者淋巴结转移的发生率有重大影响，结外侵犯是区域性和远距离衰竭的主要危险因素。早期舌癌患者临床颈部转移阴性的治疗策略应在考虑了颈部转移的可能性和选择性颈清扫术相关的发病率之后确定。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号