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首页> 外文期刊>Radiotherapy and oncology: Journal of the European Society for Therapeutic Radiology and Oncology >Intravascular ultrasound based dose assessment in endovascular brachytherapy.
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Intravascular ultrasound based dose assessment in endovascular brachytherapy.

机译：血管内近距离放射治疗中基于血管内超声的剂量评估。

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摘要

BACKGROUND: the role of endovascular brachytherapy in restenosis prevention is well documented. Dose is usually prescribed at a fixed distance from the source axis by angiographic quantification of vessel diameter. Recently, intravascular ultrasound (IVUS) was introduced in dose prescription, allowing a better evaluation of the vessel anatomy. This study retrospectively explores the difference between prescription following angiographic vessel sizing and delivered dose calculated with IVUS. METHODS AND RESULTS: Seventeen lesions were studied with IVUS, identifying on irradiated segment, three sections on which measuring minimal and maximal distance from the centre of IVUS catheter to the adventitia; using dedicated software, corresponding doses were calculated. The dose ranged widely, with maximal and minimal values of 71.6 and 4.9Gy; furthermore, heterogeneity in dose among different sections was observed. In the central section, the maximal dose was 206% of the one prescribed with the QCA model at 2 mm from the source axis, while the minimal dose was 96%. In proximal and distal sections, respective values were 182, 45, 243, and 122%. CONCLUSIONS: Our analysis confirmed the dose inhomogeneity delivered with an angiographic fixed-dose prescription strategy. A dose variation was found along the irradiated segment due to the differences in vessel thickness. IVUS emerged as an important tool in endovascular brachytherapy, especially for irregular-shaped vessels.
机译：背景：血管内近距离放射治疗在预防再狭窄方面的作用已有充分文献记载。通常通过血管直径的血管造影定量规定距源轴固定距离的剂量。最近，在剂量处方中引入了血管内超声（IVUS），从而可以更好地评估血管解剖结构。这项研究回顾性地探讨了血管造影血管大小后的处方与IVUS计算的给药剂量之间的差异。方法和结果：用IVUS研究了17个病变，在照射段上确定了三个部分，在这些部分上测量了从IVUS导管中心到外膜的最小和最大距离。使用专用软件，计算相应的剂量。剂量范围很广，最大和最小值分别为71.6和4.9Gy。此外，观察到不同切片之间剂量的异质性。在中心部分，最大剂量是距源轴2 mm处QCA模型所规定剂量的206％，而最小剂量为96％。在近端和远端部分，分别为182％，45％，243％和122％。结论：我们的分析证实了采用血管造影固定剂量处方策略所提供的剂量不均匀性。由于血管厚度的差异，沿辐照段发现剂量变化。 IVUS已成为血管内近距离治疗的重要工具，特别是对于不规则形状的血管。

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