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首页> 外文期刊>Radiotherapy and oncology: Journal of the European Society for Therapeutic Radiology and Oncology >Radiation-induced changes in skin type I and III collagen synthesis during and after conventionally fractionated radiotherapy.
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Radiation-induced changes in skin type I and III collagen synthesis during and after conventionally fractionated radiotherapy.

机译：在常规分次放疗期间和之后，辐射诱发的皮肤I型和III型胶原蛋白合成变化。

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BACKGROUND AND PURPOSE: To measure local changes of collagen metabolism in irradiated breast skin and systemic changes in serum during and after radiotherapy and correlate these changes with skin thickness, erythema and palpable subcutaneous induration. PATIENTS AND METHODS: Aminoterminal propeptides of type I and type III procollagens (PINP and PIIINP, respectively) were measured from skin suction blister fluid (SBF) in 21 breast cancer patients with breast conserving surgery and conventionally fractionated radiotherapy (RT) to a total dose of 50Gy. Suction blisters were induced in the operated and contralateral breast skin before RT, at 2.5 weeks, at the end of RT, and at 1, 4, 7, 12 and 24 months post-treatment. Blood samples for serum were taken simultaneously with SBF induction. Skin thickness of the suction blister sites was measured with a high-frequency ultrasound device. The investigated sites were scored for erythema at the end of RT and palpable subcutaneous induration at 1 and 2 years post-treatment. RESULTS: In SBF the mean levels of PINP and PIIINP of the operated breast before RT were about 3-4 times higher than those in the contralateral breast due to the operation-related wound healing. The synthesis of PINP in irradiated breast after RT increased 7.7-fold (P < 0.001) 4 months post-irradiation. The PIIINP synthesis was at maximum at 1 month post-irradiation (P < 0.001). Both synthesis stayed elevated until 2 years. The level of PINP correlated significantly with the palpable skin induration at 1 and 2 years (P = 0.038 and P = 0.003, respectively). The skin thickness of the irradiated breast was highest at 4 months post-treatment and significantly elevated until 1 year. The skin thickness correlated with the PINP level until 7 months and with PIIINP between 4 and 18 months. The PINP/PIIINP ratio reached the maximum at 4 months and stayed elevated until 2 years. No change in mean serum level of PINP was found during or after RT. CONCLUSIONS: We demonstrated a maximum and elevated levelsfor PINP and PIIINP skin collagen metabolism determined from SBF during the 2 years' follow-up. Elevated levels of PINP and PIIINP correlated with the thickening of the skin and subcutaneous induration but not with erythema.
机译：背景与目的：测量放疗期间和放疗后乳腺皮肤胶原代谢的局部变化以及血清的全身性变化，并将这些变化与皮肤厚度，红斑和可触及的皮下硬结相关。患者和方法：从21例乳腺癌保乳手术和常规分次放疗（RT）的乳腺癌患者中，通过皮肤吸水疱液（SBF）测量了I型和III型前胶原的氨基末端前肽（分别为PINP和PIIINP）。 50Gy。在放疗前，放疗后2.5周，放疗结束时以及治疗后1、4、7、12和24个月，手术和对侧乳房皮肤均会产生吸水泡。在SBF诱导的同时采集血清的血样。用高频超声设备测量吸水疱部位的皮肤厚度。在治疗结束后1年和2年，在RT结束时对所调查的部位进行红斑评分，并在明显的皮下硬结处进行评分。结果：在SBF中，由于与手术相关的伤口愈合，RT前手术乳房的平均PINP和PIIINP水平比对侧乳房高约3-4倍。放疗后4个月，放疗后辐射的乳房中PINP的合成增加了7.7倍（P <0.001）。 PIIINP的合成在辐照后1个月最大（P <0.001）。两种合成都保持升高直到2年。 PINP水平与1年和2年可触及的皮肤硬结显着相关（分别为P = 0.038和P = 0.003）。照射后的乳房的皮肤厚度在治疗后4个月最高，并在1年之前显着升高。直到7个月，皮肤厚度与PINP水平相关; 4到18个月之间，皮肤厚度与PIIINP相关。 PINP / PIIINP比值在4个月达到最大值，并保持升高直至2年。 RT期间或之后，平均血清PINP水平无变化。结论：我们证明了在两年的随访中，根据SBF确定的PINP和PIIINP皮肤胶原蛋白代谢的最高水平和升高水平。 PINP和PIIINP含量升高与皮肤增厚和皮下硬结有关，但与红斑无关。

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