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首页> 外文期刊>Radiotherapy and oncology: Journal of the European Society for Therapeutic Radiology and Oncology >Does radiation dose to the salivary glands and oral cavity predict patient-rated xerostomia and sticky saliva in head and neck cancer patients treated with curative radiotherapy?
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Does radiation dose to the salivary glands and oral cavity predict patient-rated xerostomia and sticky saliva in head and neck cancer patients treated with curative radiotherapy?

机译：唾液腺和口腔的辐射剂量是否可以预测接受根治性放疗的头颈癌患者的口干症和唾液黏稠度？

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BACKGROUND AND PURPOSE: To investigate the association between the mean salivary gland and oral cavity dose, with patient-rated moderate and severe xerostomia and sticky saliva. PATIENTS AND METHODS: One hundred and fifty-seven patients treated with bilateral irradiation for head and neck cancer were included. The parotid and submandibular glands and the oral cavity were delineated on plannings-CT scans. At baseline and 6 and 12 months self-reported xerostomia and sticky saliva were assessed using the EORTC QLQ-H&N35 questionnaire. RESULTS: At 6 months a significant association between the mean parotid (MD(par)) and mean submandibular dose (MD(subm)) and xerostomia was observed (OR - MD(par): 1.17; P=0.002 and OR - MD(subm): 1.08; P = 0.02). Between MD(par) and MD(subm), a significant interaction term was present. No significant association was found with the oral cavity dose. Xerostomia was reversible depending on MD(par) and MD(subm). Considering Sticky saliva, a significant association was found at 6 and 12 months with MD(subm) (OR: 1.03; P < 0.001). The P50 for sticky saliva increased with elapsing time. CONCLUSIONS: Both MD(par) and MD(subm) influence the risk of xerostomia in irradiated patients at 6 months. This probability as a function of the mean parotid dose significantly depended on the mean dose in the submandibular glands. Sticky saliva mainly depends on MD(subm).
机译：背景与目的：研究平均唾液腺和口腔剂量与患者评定的中度和重度口腔干燥症和唾液粘稠度之间的关系。患者和方法：157例接受了双侧照射治疗的头颈癌患者。计划CT扫描描绘了腮腺和下颌下腺以及口腔。在基线以及6个月和12个月时，使用EORTC QLQ-H＆N35问卷调查了自我报告的口干症和唾液黏性。结果：在6个月时，平均腮腺（MD（par））与平均下颌骨剂量（MD（subm））和口干症之间存在显着相关性（OR-MD（par）：1.17; P = 0.002和OR-MD（ subm）：1.08; P = 0.02）。在MD（par）和MD（subm）之间，存在重要的交互作用项。没有发现与口腔剂量有显着关联。口干症是可逆的，取决于MD（par）和MD（subm）。考虑到唾液黏稠，在第6和12个月时发现其与MD（subm）有显着相关性（OR：1.03; P <0.001）。粘性唾液的P50随着时间的流逝而增加。结论：MD（par）和MD（subm）均会影响6个月受辐照患者发生口干症的风险。作为腮腺平均剂量的函数，该概率显着取决于下颌下腺的平均剂量。粘性唾液主要取决于MD（subm）。

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