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首页> 外文期刊>Radiotherapy and oncology: Journal of the European Society for Therapeutic Radiology and Oncology >Erythropoietin receptor is not a surrogate marker for tumor hypoxia and does not correlate with survival in head and neck squamous cell carcinomas.
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Erythropoietin receptor is not a surrogate marker for tumor hypoxia and does not correlate with survival in head and neck squamous cell carcinomas.

机译：促红细胞生成素受体不是肿瘤缺氧的替代标志物，并且与头颈部鳞状细胞癌的存活率不相关。

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BACKGROUND AND PURPOSE: To evaluate erythropoietin receptor (EPOR) expression in human head and neck squamous cell carcinomas and correlate this to the presence of tumor hypoxia and treatment outcome. PATIENTS AND METHODS: Eighty-five patients with locally advanced tumors of the head and neck were included. Of these, 34 were given the hypoxia marker pimonidazole i.v. 2 h prior to biopsy taking. Contiguous paraffin embedded biopsies were stained for EPOR expression and, if administered, for pimonidazole binding. Immunohistochemical staining for EPOR was interpreted semiquantitatively according to a composite scale, ranging from 0 to 200. Pimonidazole positivity was quantitatively analyzed in a semiautomatic way. RESULTS: Diffuse weak-to-moderate cytoplasmic and membrane EPOR immunostaining was observed in 80 of 85 biopsies (94%) and staining scores ranged from 0 to 198 (median 100). No correlations were found between EPOR expression, and the primary tumor site, T-stage or N-stage. Also, There was no association between EPOR expression and treatment outcome. The degree of tumor hypoxia represented by the relative area of pimonidazole binding varied between 0 and 26% (median 7%). Contiguous biopsy sections showed a lack of colocalization between EPOR and pimonidazole binding. CONCLUSION: EPOR expression was demonstrated in the majority of the head and neck tumors. No colocalization was found between EPOR expression and pimonidazole binding indicating that the presence or absence of hypoxia did not necessarily indicate a distinct pattern of EPOR expression. The level of EPOR expression was not of prognostic significance in patients with head and neck cancer, although small effects of EPOR cannot be excluded because of the sample size of this study.
机译：背景与目的：评估促红细胞生成素受体（EPOR）在人头颈部鳞状细胞癌中的表达，并将其与肿瘤缺氧的存在和治疗结果相关联。患者和方法：包括八十五例头部和颈部局部晚期肿瘤的患者。其中34个患者接受了缺氧标记物pimonidazole i.v.活检前2小时。连续石蜡包埋的活检标本进行EPOR表达染色，如果给药，则进行吡莫硝唑结合染色。对EPOR的免疫组织化学染色根据复合标度从0到200进行半定量解释。吡莫尼唑阳性率以半自动方式定量分析。结果：85例活检中有80例（94％）观察到弥漫性弱至中度的细胞质和膜EPOR免疫染色，染色评分范围为0至198（中位数100）。在EPOR表达与原发肿瘤部位，T期或N期之间未发现相关性。而且，EPOR表达与治疗结果之间没有关联。以吡莫硝唑结合的相对面积表示的肿瘤缺氧程度在0到26％之间（中位数为7％）变化。连续的活检切片显示，EPOR和pimonidazole结合之间缺乏共定位。结论：大多数头颈部肿瘤均表现出EPOR表达。在EPOR表达和吡莫硝唑结合之间未发现共定位，表明存在或不存在缺氧并不一定表明EPOR表达的独特模式。尽管由于本研究的样本量不能排除EPOR的微小影响，但EPOR表达水平在头颈癌患者中没有预后意义。

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