...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Radiotherapy and oncology: Journal of the European Society for Therapeutic Radiology and Oncology >Partial volume rat lung irradiation: The protective/mitigating effects of Eukarion-189, a superoxide dismutase-catalase mimetic.
【24h】

Partial volume rat lung irradiation: The protective/mitigating effects of Eukarion-189, a superoxide dismutase-catalase mimetic.

机译：大鼠肺部容积照射：超氧化物歧化酶-过氧化氢酶模拟物Eukarion-189的保护/缓解作用。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

BACKGROUND AND PURPOSE: The purpose of the current study was to elucidate the protective/mitigating effects of a SOD-catalase mimetic, Eukarion-189 (EUK-189), on DNA damage in rat lung following irradiation. The particular focus of these studies was the efficacy of EUK-189 when given after irradiation (mitigation). PATIENTS AND METHODS: We exposed whole or lower lungs of female Sprague-Dawley rats to doses ranging from 10 to 20.5Gray (Gy) of (60)Co gamma rays. Animals in the EUK-189 treated groups received 2 or 30mg/kg intraperitoneally (i.p.) at various times postirradiation (PI). A micronucleus assay was used to examine DNA damage at various times up to 16 weeks PI. RESULTS: Our results indicated that EUK-189 administration after irradiation is effective at reducing micronucleus formation in lung fibroblasts at various times following radiation exposure. Treatment with EUK-189 in the first 3 days after thoracic irradiation did not, however, modify the dose required to cause severe morbidity at 2-3 months after irradiation. CONCLUSIONS: The protection produced when Eukarion-189 was given shortly after irradiation suggests that DNA damage observed in the lung may be caused by chronic production of ROS induced by a chronic inflammatory response initiated by the radiation treatment. We speculate that our failure to observe protection against severe morbidity at 2-3 months may be because our treatment regime only blocked the initial wave of ROS production and that treatment needs to be more prolonged to suppress the effects of a chronic inflammatory response.
机译：背景与目的：本研究的目的是阐明模拟SOD过氧化氢酶Eukarion-189（EUK-189）对辐射后大鼠肺部DNA损伤的保护/缓解作用。这些研究的重点是辐射（缓解）后给予EUK-189的功效。患者与方法：我们将雌性Sprague-Dawley大鼠的整个或下肺暴露于剂量为10至20.5格雷（Gy）的（60）Coγ射线。 EUK-189治疗组的动物在放射后（PI）的不同时间腹膜内（i.p.）接受2或30mg / kg。微核试验用于检查直至PI 16周的不同时间的DNA损伤。结果：我们的结果表明，辐射后给予EUK-189可有效减少辐射暴露后不同时间的肺成纤维细胞中的微核形成。但是，在胸腔照射后的前三天用EUK-189进行治疗并没有改变在照射后2-3个月引起严重发病所需的剂量。结论辐射后不久给予Eukarion-189产生的保护作用表明，在肺部观察到的DNA损伤可能是由放射治疗引起的慢性炎症反应引起的ROS长期产生引起的。我们推测我们未能在2-3个月时观察到针对严重发病的保护措施可能是因为我们的治疗方案仅阻止了ROS的产生，并且需要进一步延长治疗时间以抑制慢性炎症反应的发生。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号