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首页> 外文期刊>Radiotherapy and oncology: Journal of the European Society for Therapeutic Radiology and Oncology >Microsatellite alterations in head and neck squamous cell carcinoma and relation to expression of pimonidazole, CA IX and GLUT-1.
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Microsatellite alterations in head and neck squamous cell carcinoma and relation to expression of pimonidazole, CA IX and GLUT-1.

机译：头颈部鳞状细胞癌中的微卫星改变及其与吡莫硝唑，CA IX和GLUT-1的表达相关。

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BACKGROUND AND PURPOSE: Because the locoregional control for HNSCC is still disappointing, research efforts focus on the exploration of new molecular markers located in both tumour and microenvironment, which could help stratify patients. The aim of the present work was therefore first to assess microsatellite alterations and hypoxia in HNSCC as possible molecular markers. Second, a relation between both was investigated, as hypoxia is known to select for genetic alterations. MATERIAL AND METHODS: Forty-eight patients with advanced HNSCC treated by surgery+/-radiotherapy were included. MSI and LOH were investigated with microsatellite markers using automatic fragment analysis. The presence of hypoxia was assessed by immunohistochemistry for pimonidazole, CA IX and GLUT-1. The mutual relationship between MSI/LOH and hypoxia was evaluated. RESULTS: No MSI was detected in this patient group. LOH occurred mostly on chromosomal arms 3p, 5q, 9p, 17p and 17q. Patients with LOH at D17S799, located in the near environment of p53, showed a higher CA IX expression (p=0.01). CONCLUSIONS: LOH is a possible molecular marker in HNSCC. The positive correlation between LOH at D17S799 and CA IX is in full concordance with previous publications linking hypoxia to selective pressure on the p53 gene.
机译：背景与目的：由于HNSCC的局部控制仍令人失望，因此研究工作集中于探索位于肿瘤和微环境中的新分子标记，这有助于对患者进行分层。因此，本研究的目的是首先评估HNSCC中微卫星的改变和缺氧作为可能的分子标记。其次，研究了两者之间的关系，因为已知缺氧会选择遗传变异。材料与方法：纳入四十八例经手术放疗治疗的晚期HNSCC患者。使用自动片段分析，使用微卫星标记对MSI和LOH进行了研究。通过免疫组织化学评估吡莫尼唑，CA IX和GLUT-1的缺氧情况。评估了MSI / LOH与缺氧之间的相互关系。结果：该患者组未检测到MSI。 LOH主要发生在染色体臂3p，5q，9p，17p和17q上。位于p53附近环境中的D17S799的LOH患者显示较高的CA IX表达（p = 0.01）。结论：LOH是HNSCC中可能的分子标记。 D17S799处的LOH与CA IX之间的正相关与先前的出版物（将缺氧与p53基因的选择性压力相关联）完全一致。

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