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首页> 外文期刊>Radiotherapy and oncology: Journal of the European Society for Therapeutic Radiology and Oncology >Effect of increase of radiation dose on local control relates to pre-treatment FDG uptake in FaDu tumours in nude mice.
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Effect of increase of radiation dose on local control relates to pre-treatment FDG uptake in FaDu tumours in nude mice.

机译：辐射剂量增加对局部控制的影响与裸鼠FaDu肿瘤中FDG的预处理摄入有关。

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OBJECTIVES: To investigate whether heterogeneity in [(18)F]2-fluoro-2-deoxy-d-glucose (FDG) uptake in a single tumour line, i.e. in tumours with identical genetic background, relates to radiation response. MATERIALS AND METHODS: Sixty-two human FaDu head and neck squamous cell carcinomas in nude mice with a diameter of 7mm entered the study. FDG-PET scanning was performed without anaesthesia on an animal PET scanner immediately prior to irradiation in order to determine maximum standardized uptake values (SUV(max)). Single dose irradiations of 25 or 35Gy were applied under normal blood flow conditions using 200kV X-rays (0.5mm Cu, approximately 1.2Gy min(-1)). The mice were observed for 120 days after irradiation, experimental endpoint was local tumour control evaluated using the Kaplan-Meier method. RESULTS: Analyzing all 62 animals, tumour control probability after irradiation with 25Gy was significantly lower than after irradiation with 35Gy (29% vs. 57%, log rank p=0.016). Pre-treatment SUV(max) values ranged from 0.72 to 3.47, the median SUV(max) value was 1.59. In tumours with FDG uptake less than the median SUV(max), local control was 37% after 25Gy vs. 47% after 35Gy (p=0.37). In contrast, substantial differences in local tumour control were found in tumours with FDG uptake above the median SUV(max) (24% vs. 71%, p=0.006). Multivariate Cox analysis revealed a significant decrease of hazard of recurrence with increasing dose and SUV(max). CONCLUSIONS: An increase of radiation dose had a greater effect on local control in FaDu tumours with higher FDG uptake than in tumours with lower FDG uptake. This supports the hypothesis that pre-treatment FDG-PET may provide useful information for heterogeneous radiation dose prescription in subvolumes of tumours of individual patients. As only one tumour model was studied and single doses were applied, confirmatory investigations using further tumour models and fractionated radiotherapy are warranted.
机译：目的：研究在单个肿瘤细胞系，即具有相同遗传背景的肿瘤中，[（18）F] 2-氟-2-脱氧-d-葡萄糖（FDG）摄取的异质性是否与放射反应有关。材料与方法：直径为7mm的裸鼠中的62例人类FaDu头颈部鳞状细胞癌进入研究。刚要在辐照之前在动物PET扫描仪上进行FDG-PET扫描而无需麻醉，以确定最大标准化摄取值（SUV（max））。在正常血流条件下，使用200kV X射线（0.5mm Cu，约1.2Gy min（-1））进行25或35Gy的单剂量照射。照射后120天观察小鼠，实验终点是使用Kaplan-Meier方法评估的局部肿瘤对照。结果：分析所有62只动物，用25Gy照射后的肿瘤控制概率显着低于用35Gy照射后的肿瘤控制概率（29％比57％，对数等级p = 0.016）。预处理SUV（max）值介于0.72至3.47之间，中位数SUV（max）值为1.59。在FDG摄取小于中位数SUV（max）的肿瘤中，25Gy后局部控制为37％，而35Gy后局部控制为47％（p = 0.37）。相反，FDG摄取高于中位数SUV（max）的肿瘤在局部肿瘤控制方面存在实质性差异（24％vs. 71％，p = 0.006）。多元Cox分析显示，随着剂量和SUV（max）的增加，复发的风险显着降低。结论：增加FDG摄取的FaDu肿瘤的辐射剂量对FDU摄取较低的肿瘤的局部控制影响更大。这支持了以下假设：治疗前的FDG-PET可能为个体患者肿瘤亚体积中的异质辐射剂量处方提供有用的信息。由于仅研究了一种肿瘤模型并应用了单剂，因此有必要使用进一步的肿瘤模型和分级放疗进行确证研究。

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